But most of the antigen was the kind of self-antigen with the defects of poor-immunogenicity and easily-caused immunotolerance. 但这些抗原多属自身抗原,普遍存在免疫原性低,易引起免疫耐受等缺陷。
Immune cross-reaction of Mycobacterium tuberculosis MAb with self-antigen histone was demonstrated by Western blot. 结核分枝杆菌的单抗与自身抗原组蛋白能发生免疫交叉反应。
STZ destroys insulin and existence of self-antigen, meanwhile, results in the occurrence of autoimmune diabetes mellitus. 在STZ破坏胰岛细胞,自身抗原存在的同时,导致了自身免疫糖尿病的发生。
Some antigen specific CD8+ T lymphocytes can recognize the self-antigen in the surface of islet beta cells which presented by MHC class I, then they will kill islet beta cells by cytotoxic effect. 抗原特异性CD8+T淋巴细胞可以识别胰岛β细胞表面由MHC-Ⅰ类分子递呈的自身抗原肽,通过分泌穿孔素和颗粒酶等机制发挥细胞毒作用,从而破坏胰岛β细胞。
There exists a sequential hierarchy in self-reactive T-cellular responses directed against these islet autoantigens, and the T-cellular response against insulin is viewed to be upstream of the responses to other self-antigen. 自身反应性T细胞针对这些抗原的反应存一定的等级,自身反应性T细胞对胰岛素抗原的识别反应被认为是位于对其他抗原反应的上游。
But Flk-1 is self-antigen. A major challenge is to break the immune tolerance and induce a robust, long-lived T cell-mediated immunity which leads to an effective suppression of tumor angiogenesis. 但Flk-1属自身抗原,研究人员面临如何才能增强其免疫原性,打破免疫耐受激发有效免疫应答的难题。