They act on the aromatic residues of AChE by Π-Π conjugation. ( 4) The reached results by Comparative Molecular Field Analysis ( CoMFA) is useful to design new higher efficacy derivatives for 1, 2, 4-oxadiazole class nonquaternary Cholinesterase Reactivators. 通过比较分子力场法(CoMFA)研究可以指导1,2,4-oxadiazole类非季铵肟胆碱酯酶重活化剂新化合物的合成,可能得到活性更高的复能剂。
Studies on structure-activity relationship and mechanism of nonquaternary AChE reactivators 一类非季铵型重活化剂的构效关系及其作用机理的研究
The CoMFA study on nonquaternary cholinesterase reactivators: 1,2,4-oxadiazole derivatives 1,2,4-oxadiazole类非季胺肟胆碱酯酶重活化剂的CoMFA研究