The primary end point was a change in the fraction of glomerular volume occupied by mesangium in kidney-biopsy specimens. 首要终点是肾脏活检标本中系膜细胞占肾小球体积的比例变化。
Objective: IgA nephropathy ( IgAN) is a mesangial proliferative glomerulonephritis in which IgAl predominantly deposits in glomerular mesangium. 目的:IgA肾病是以肾小球系膜区IgA沉积为主的系膜增生性肾小球肾炎,其发病机理至今未明。
Immunofluorescence of IgG and C3 with the intensity of 3+-4+ was also found in mesangium region of model group. 免疫荧光显示IgG和C3沉积于系膜区(3+~4+)。
Type ⅰ collagen began to express in glomeruli when average numbers of mesangial cells were more than 4 within one mesangium area and it was positive in sclerotic glomeruli. 当系膜区系膜细胞超过4个时,Ⅰ型胶原开始在肾小球内出现,且在硬化肾小球内Ⅰ型胶原均呈阳性;
Results: Hyperplasia of mesangium, interstitial infiltration of inflammatory cells, degeneration of renal tubular epithelial cells, dilatation of tubules, and other changes were observed in alcohol group. 结果:中药组同酒精组比较,肾小球系膜增殖、间质局灶性炎性细胞浸润、肾小管上皮扁平化和肾小管扩张等病理改变出现延迟且明显减轻。
Conclusion: Shenbining maybe induce the apoptosis of mesangium cell to inhibit the mesenteric proliferation by regulating the expression of Fas/ Fasl. 结论:肾必宁可能通过调控Fas/FasL的表达而诱导系膜细胞凋亡,进而抑制系膜增殖。
Results showed that MC proliferation and matrix accumulation in glomeruli were suppressed, electron dense deposits in mesangium were decreased in treatment group as compared with model group. The mesangial area proportion in glomerular capillaries area in model group was significantly higher than normal group and treatment group. 结果:治疗组与模型对照组比较,肾小球系膜细胞(MC)的增生和系膜基质的积聚明显受到抑制,系膜区致密电子物沉积显著减轻;
[ Results] IL-6 antisense oligonucleotide labeled by FAM injection was expressed lightly in the glomerular mesangium one hour after injection, but expressed significantly 6 hours after injection. [结果]FAM标记的IL-6反义寡核苷酸经左肾动脉注入后1h,系膜区可检测到少量表达,6h后肾系膜区表达明显增加。
The results were as follows: 1) There was diffuse and uneven thickening of the glomerular basement membrane ( GBM) and mesangium in NIDDM. 结果:(1)糖尿病肾小球基底膜(GBM)和系膜基质呈弥散和不均匀性增厚。
Influence of "Kidney Peace Granules" on Apoptosis of Mesangium Cell and bcl-2 and ICE Genetic Expression 肾必宁冲剂对肾小球系膜细胞凋亡及bcl-2、ICE基因表达的影响
Conclusion ILK expression in the mesangium is dramatically increased and correlated with that of FN, suggesting that ILK may increase extracellular matrix deposition and be involved in mesangial matrix expansion in the pathogenesis of diabetic glomerulosclerosis. 结论ILK在糖尿病肾病肾组织中表达量显著增加,并与FN的表达有一定的相关性,说明其可能通过促进细胞外基质FN等的积聚,在糖尿病肾小球硬化过程中发挥重要作用。
Conclusion: Astragalus Membranaceus had therapeutical effects to Doxorubicin nephropathy through its influence on mesangium and mesangial cells. 结论:黄芪通过影响系膜区和系膜细胞而对多柔比星肾病产生治疗作用。
The mesangium was extended. 系膜旁区增生扩大。
Electron microscope showed that mesangium region enlarged with obvious electron dense deposits, and foot process fusion was seen extensively in model group. 电镜结果显示模型组小鼠肾小球系膜区有明显电子致密物沉积,足突融合;
Results The serum IgA-fibronectin complex was increased in IgA nephropathy rats and correlated with the intensity of IgA in mesangium. 结果IgA肾病时,血清IgA纤维连接蛋白聚合物水平升高,并与系膜IgA沉积呈正相关。
In FSGS, there are two types expression of C4d, Linear deposition in basal membrane and granulo-form or bolus-form deposition in mesangium. Linear deposition of C4d are present the higher activation of classical pathway of complement, and indicate the poor prognosis and hormone resistance. 2. FSGS中C4d沉积方式有两种:基底膜线状沉积和系膜区颗粒、团块状沉积。线状沉积代表经典补体途径更强激活,提示患者预后较差和对激素治疗不敏感。
In group DM glomerular basement membrane thickening, a large number of mesangium matrix deposition, vacuolar degeneration of tubular epithelial cells, renal interstitial fibrosis and mononuclear cells and lymphoid cell infiltration appears. 糖尿病组大鼠肾小球毛细血管基底膜增厚,系膜区基质大量沉积,肾小管上皮细胞空泡样变性,肾间质出现纤维化及单核细胞和淋巴样细胞浸润。