Further experiments indicated that the serum inhibitory activity originated from IgG fractions, the cytotoxic effect was either complement-dependent or independent, on both allogeneic and autologous megakaryocyte progenitor cells, and specifically directed at megakaryocytic lineage. 进一步实验表明,血清抑制活性源自IgG组分,其细胞毒作用依赖或不依赖补体,对异体和自身巨核细胞均起作用,并特异性针对巨核系。
Objective To assess the clinical features, immunophenotypic, and cytogenetic characteristics of acute megakaryocytic leukemia ( AMKL). 目的分析急性巨核细胞白血病(AMKL)患者的临床特征、免疫表型、分子生物学特征以及预后。
Methods: Detailed clinical manifestations and laboratory features of a patient with acute megakaryocytic leukemia were presented. 方法:报告1例急性巨核细胞白血病的临床及实验室特征;
The preliminary study of transient atypical megakaryocytic hyperplasia in bone marrow during chemotherapy for acute myeloid leukemia 急性髓细胞白血病化疗期骨髓一过性不典型巨核细胞增生的初步研究
The expression of interleukin-1 ( IL-1) to interleukin-10 ( IL-10), TNF-α, TNF-γ and IFN-γ on the four megakaryocytic cell lines was also determined by RT-PCR. 使用RTPCR方法,检测白细胞介素1(IL1)至白细胞介素10(IL10),TNFα,TNFγ和IFNγ在4个巨核细胞株的表达;
Studies on some characteristics of proliferation and differentiation of mouse megakaryocytic progenitors 小鼠巨核系祖细胞增殖、分化特性的研究
Megakaryocytic progenitor colony formation and megakaryocytic maturation were observed through megakaryocytic culture in vitro, and the effect of CD80 McAb on megakaryocytic progenitor colony formation and megakaryocytic maturation in CITP was studied. 通过巨核细胞体外培养观察CITP的巨核细胞生长和成熟,并观察CD80单抗对其的影响。
It is concluded that TPO/ FL/ IL-6/ IL-3 combination was the best optimal for expansion ex vivo of megakaryocytic progenitors from MPB, and its suitable duration of culture was 10 days; 结论以TPO/FL/IL-6/IL-3因子组合为体外诱导扩增巨核祖细胞的最佳组合,动员外周血的巨核祖细胞体外诱导扩增以培养第10天为宜。
Conclusion It is possible that the CD34~+ cells could be induced and differentiate to megakaryocytic progenitors in the optional combination of HGFs. 结论脐血CD34+细胞体外在相关细胞生长因子的刺激下可向巨核细胞系定向分化。
The growth of M-07e human megakaryocytic leukemia cells is strictly dependent on GM-CSF. 人巨核白血病细胞系M07e的生长严格依赖于GMCSF。
Ginsenosides Stimulate Proliferation of Human Megakaryocytic Progenitors Through by Ginsenosides GATA Transcription Factor 人参皂甙通过GATA转录因子刺激巨核系祖细胞增殖
The results suggested that megakaryocytopoiesis was regulated by several cytokines and that TPO was a megakaryocytic lineage specific cytokine. 该结果显示,人巨核细胞增殖受多种造血生长因子调控,其中TPO是特异地调控人巨核祖细胞生长的一种细胞因子。
The results showed that there were abnormal hematopoiesis in granulocyte series, erythron series and megakaryocytic series in different extent. 结果:粒、红、巨核三系均有不同程度的病态造血表现。
Effect in vitro of immunologic factors on megakaryocytic progenitors growth and maturation in patients with CITP 免疫因子对慢性免疫性血小板减少性紫癜骨髓巨核祖细胞体外生长的影响
Report on eight cases of pure megakaryocytic aplasia 单纯巨核细胞再生障碍8例报告
Objective To explore the restorative effect of intestinal RNA on injuries of granulocyte and megakaryocytic series in mice after abdominal γ-irradiation. 目的探讨小肠RNA在促进肠道辐射损伤恢复的同时对受照射小鼠粒系和巨核细胞系损伤的恢复作用。
Objective: To describe the finding of atypical megakaryocytic hyperplasia ( AMH) during chemotherapy for AML other than acute megakaryoblastic leukemia. 目的探讨急性巨核细胞白血病(FAB-M7)以外的急性髓细胞白血病(AML)患者化疗期间一过性不典型巨核细胞增生(AMH)现象。
Apoptosis Effect of Imatinib on Primary Acute Megakaryocytic Leukemia Cells Expressing BCR/ ABL 伊马替尼对BCR/ABL融合基因阳性的急性巨核细胞白血病原代细胞凋亡作用的研究
Apoptotic cells derive mainly from granulocytic, erythroid and megakaryocytic hematopoietic lines. Three. 凋亡细胞主要来源于三系造血细胞。
Research on the effects of Yi Sui Ling Mixture and Its Part on Morbid Hematopoietic Cells of Megakaryocytic Series 益髓灵及其拆方对巨核系病态造血细胞影响的研究
Only 4 cases had comparatively typical change of megakaryocytic series. 巨核细胞系仅4例发现较典型改变。
They thought it might be a penetrating point of research on MDS with TCM to establish animal model of MDS, improve the morbid hematopoiesis of marrow megakaryocytic series of these patients and increase their peripheral platelet numbers. 同时建议把探索建立MDS动物模型和改善MDS患者骨髓巨核系病态造血以及提高患者周围血小板数值作为中医药研究的突破口。
Recently, arsenic trioxide was found to be capable of inducing apoptosis of cell lines those origin from myeloblastic, lymphoblastic, megakaryocytic and plasmocytic malignant hematological diseases. 近年来,国内外学者发现As2O3在体外能诱导髓系、淋系、巨核系和浆细胞等来源的恶性血液病细胞株的凋亡,并从许多方面对其机制进行了研究。