Objective To observe the effect of mefloquine on the tegument of adult Schistosoma japonicum harbored in mice. 目的观察甲氟喹对感染小鼠体内日本血吸虫成虫皮层的损害。
History of quinine, mefloquine, or quinidine-induced thrombocytopenia, hepatitis, bone marrow depression, lupus-like syn drome. 对奎宁,甲氟喹或奎尼丁引起的血小板减少症,肝炎,骨髓抑制,狼疮样综合征的历史。
Resistance along the Thai-Cambodia border started with chloroquine, followed by resistance to sulfadoxine-pyrimethamine and mefloquine, drugs used in malaria control several years ago. 泰柬边界地区一开始出现的是对氯喹的耐药性,然后对周效磺胺-乙胺嘧啶以及甲氟喹产生耐药性。这些药是几年前使用的抗疟药。
Conclusion Mefloquine causes focal swelling of worm body, extensive and severe damage to the tegument in adult S.japonicum. 结论甲氟喹可引起血吸虫成虫虫体局部肿大和广泛严重的皮层损害。
Objective To evaluate the clinical efficacy of dihydroartemisinin& mefloquine on acute uncomplicated falciparum malaria. 目的观察双氢青蒿素与甲氟喹联用治疗急性无并发症恶性疟疾的临床疗效。
RESULTS: Except for the absence of resistance to mefloquine and quinine, the resistance rate of the parasite to chloroquine, amodiaquine and piperaquine was 84 6%, 86 1% and 38 0% respectively. 结果:甲氟喹和奎宁分别测定36例和33例,未发现抗性病例。氯喹、氨酚喹和哌喹抗性率分别为84.6%、86.1%和38.0%。
Study on effect of combination of artemether and mefloquine in the treatment of patients with chloroquine resistant falciparum malaria 蒿甲醚与甲氟喹联合用药治疗抗氯喹株恶性疟的研究
Susceptibility of Plasmodium falciparum to chloroquine, piperaquine, amodiaquine, mefloquine and quinine with in vitro microtechnique in Hainan Island 应用体外微量法测定海南岛恶性疟原虫对氯喹、喹哌、氨酚喹、甲氟喹及奎宁的敏感性