This has allowed the identification of and longitudinal follow-up of many LQTS patients who would not otherwise have been diagnosed as LQTS patients. 这使得可对许多其它方法未能诊断的长Q-T综合征患者得以识别,并对他们进行纵向的随访观察。
Most patients with definite LQTS ( 78%) who underwent genetic testing proved to have an LQTS-causing mutation, the report indicates, as did34% of patients with possible LQTS. 此报道提示大多数(78%)确诊为长QT间期综合症的患者接受基因测试,被证实有长QT间期综合症的基因突变。
A novel feature of his clinical research has been the study of large families with LQTS, with prospective screening of many extended family members of each probands. 他具有特色的临床研究是对一大的遗传性长Q-T综合征家系,前瞻性筛查每位先证者的家庭成员。
Mutations in genes for inherited LQTS are also associated with much more common drug-induced LQTS. 遗传性LQTS致病基因的突变也与很多普通药物诱导的LQTS相关。
There is a significant difference in the pattern of disordered ion channels between the congenital long QT syn-drome ( LQTS) and the acquired heart disease. 离子通道的病变类型在先天性LQTS与后天性心脏病中有明显的不同。
Objective To observe the QT interval changing during exercise testing in patients with children ′ s long QT syndrome ( LQTS), and uo explore the new diagnosis methods of LQTS. 目的观察儿童先天性长QT综合征(LQTS)患者进行运动试验时QT间期的变化。
Objective To explore the mechanism of the left cardiac sympathetic denervation ( LCSD) surgery to reduce the incidence of cardiac events for long QT syndrome ( LQTS) patients. 目的探讨左心交感神经切除术(LCSD)降低长QT综合征(LQTS)患者心脏事件发生率的机制。
The affected ion channel in congenital LQTS is single. 先天性LQTS是单一离子通道的改变。
Specific ion channel mutations underline the congenital long QT syndrome ( LQTS). 特定离子通道的基因突变是产生遗传性长QT综合征的基础。
The emphasis in the therapy of inherited LQTS was the use of β-adrenoceptor blocking agents. 先天性LQTS治疗的重点是使用β受体阻滞剂;
The objective of this study is to identify mutations in patients of LQTS in Chinese. 目前,中国人LQTS基因突变的报道较少,本研究目的是找到中国LQTS基因突变。
Objective: To identify the gene mutation in a Chinese family of congenital long QT syndrome ( LQTS). 目的:检测并分析一中国先天性长QT综合征(congenitallongQTsyndrome,LQTS)家系的基因突变。
The hereditary long QT syndrome ( LQTS) is a cardiac disorder characterized by prolongation of the QT interval on electrocardiograms ( ECGs), syncope and sudden death. 遗传性长QT综合征(LQTS)是一种常染色体遗传性心脏病。特征性表现为心电图上QTc延长,及尖端扭转型室性心动过速(TdP)导致的晕厥和猝死。
Objectives To identify the ankyrin-B gene mutations that cause long QT syndrome ( LQTS) and determine the prevalence of such mutations in Japanese patients with LQTS. 目的确定ankyrin-B基因突变在日本人群QT间期延长综合征中的发病率以及ankyrin-B基因突变与QT间期延长综合征之间的关系。
To study the clinical manifestations and therapy of Chinese long QT syndrome ( LQTS) patients. According to the criteria by Schwartz 1993, 76 patients who came from 18 provinces were diagnosed as LQTS. 为研究我国长QT综合征(LQTS)患者的整体发病和治疗情况,选择按照1993年Schwartz等提出的LQTS诊断标准确诊为本病的家系76个。
Gene-specific therapy and genetic testing are now available for LQTS and Brugada syndrome ( BS). 基因特异性治疗和遗传诊断已经应用于LQTS和Brugada综合征。
Investigate the genetic regular, clinical characteristics, diagnosis of long QT syndrome ( LQTS) and try to find out the phenotype and genotype of the LQTS family patients. 调查与分析6个先天性长QT综合征(LQTS)家族的发病情况、临床和心电图特点以及相应的表现型和基因型。
The electrophysiology and endocardial monophasic action potential ( MAP) recording in three patients with long QT interval syndrome ( LQTS) and TdP of different etiology were studied. 本文对3例不同病因的长QT间期综合征(LOTS)伴TdP的电生理和心内膜单相动作电位记录进行了研究。
Conclusions U wave has different origin from the T wave for the LQTS patients and U wave should not be included for the QT measurement in LQTS diagnosis. 结论LQTS患者的U波与T波具有不同的起源机制,因此在诊断LQTS测量QT间期时不应包含U波。
Conclusion: It is a useful method to diagnosis and distinguishes from types of LQTS by family investigation and ECG analysis. 结论:通过家族调查和心电图分析,可以基本准确的诊断LQTS,推测相应的基因型。
Patients with Torsade de Pointes ( TdP) associated with QT interval prolongation, i. e. the long QT syndromes ( LQTS), were analyzed. All the patients were females. 本文分析八例伴Q&T间期延长的尖端扭转型室速(TdP),即长QT综合征(LQTS)。
Objective To carry out clinical and molecular genetic analyses in a big kindred including four generations with long QT syndrome ( LQTS) and to explore the genotype-phenotype interrelationships between kindred members. 目的对一祖孙四代的QT延长综合征(LQTS)家系进行临床研究及分子遗传学分析,并揭示该家系成员基因型与基因表型之间的关系。
Results Among 187 family members there were 31 symptomatic patients with LQTS, including 11 males and 20 females. 结果187个家庭成员中有31例为LQTS患者,男性11例,女性20例。
In addition to QT prolongation on the surface ECG in LQTS, T wave alternans, T wave notching, TU fusion and RR interval prolongation are common findings when syncope or ventricular tachycardia occurs. LQTS的心电图上除QTc延长外,T波电交替,T波切迹,TU融合,和RR间期延长在症状发作时均较常见。
The neonatal CH screening is the effective means to find out CH. Conclusion Molecular study can provide useful tool for the presymptomatic and accurate diagnosis for LQTS. 进行新生儿筛查是发现CH的有效手段。结论基因筛查进行早期和准确的诊断。
Objective To study the clinical manifestations and gene mutations of Chinese long QT syndrome ( LQTS) patients. 目的研究我国长QT综合征(LQTS)病人的临床特征和基因突变特点。
There has been correlation between the specific genotype ( LQT1and LQT2type) and phenotype of Chinese LQTS patients, and basically the same as reports. 2. 结论1、中国LQTS患者特定基因型(LQT1型和LQT2型)与表现型存在关联,与国外报道基本一致。