Effects of levothyroxine on spatial learning and memory deficiency of amyloid β-protein-induced dementia mice 左甲状腺素对淀粉样β蛋白所致痴呆模型小鼠空间学习记忆的影响
Due to TT? s advanced age and history of cardiac disease, the pharmacist should call the prescriber to discuss a decrease in the levothyroxine dose. 由于TT年龄较大,而且有心脏病病史,药师应要求开方医生减少左旋甲状腺素的剂量。
The type of thyroid replacement medication that should be used during pregnancy is clearly stated: oral levothyroxine only. 指南中明确指出在孕期应用的甲状腺激素替代药物的类型:只能使用口服左旋甲状腺素。
Conclusion The administration of levothyroxine to patients with primary hypothyroidism can increase the level of myocardial enzymes and decrease significantly the level of TC and LDL-C. 结论原发性甲减患者应用左旋甲状腺素治疗后可显著降低TC、LDL-C及心肌酶谱水平。
The FDA revised the specification last year after evaluating stability data from all levothyroxine sodium products. 去年,FDA在评估了所有左甲状腺素钠产品的稳定性数据后修订了质量标准。
The Intellective Influence of Levothyroxine to Subclinical Hypothyroidism in Children 左旋甲状腺素片对亚临床甲减患儿智力影响作用观察
What concerns should the pharmacist have regarding TT? s new levothyroxine prescription? 那么药师对TT新开的左旋甲状腺素片处方应给予怎样的关注呢?
Determination of Content and Dissolution of Levothyroxine Sodium Tablet by RP-HPLC RP-HPLC法检测左旋甲状腺素钠片剂含量及溶出度
The effects of levothyroxine replacement therapy on bone and mineral metabolism in patients with hypothyroidism 左旋甲状腺素替代治疗对甲状腺功能低减患者骨矿代谢的影响
The drug interactions and mechanism of levothyroxine sodium with other drugs 左甲状腺素钠的药物相互作用及机制初探
The Relationship Between CHD and Subclinical Hypothyroidism Effects of Levothyroxine Treatment on Patients with Subclinical Hypothyroidism 左旋甲状腺素对亚临床甲状腺功能减退患者的治疗作用
Suppressive therapy of levothyroxine for benign multiple thyroid nodule Inhibition 左旋甲状腺素对良性多发性甲状腺结节的抑制性治疗
Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism 甲状腺功能减退妇女妊娠期增加左旋甲状腺素的时机和剂量
CONCLUSION: The relative bioavailability of new levothyroxine sodium tablet is ( 102 ± 18)%. The new and old levothyroxine sodium tablets are bioequivalent. 结论:新配方和旧配方左甲状腺素钠片剂相对生物利用度为(102±18)%,2种配方的制剂具有生物等效性。
Conclusion The large starting doses of levothyroxine can treat the abnormal TSH level more early, and lead to the normal development and growth of children with CH. 结论大L-T4初始量治疗能较早的纠正TSH,使CH患儿正常生长发育。
Results: The mean initial dose of levothyroxine in 138 cases was ( 4.3 ± 0.9)μ g/ ( kg. d). 结果:138例患儿左旋甲状腺素起始平均剂量为(4.3±0.9)μg/(kg.d)。
The Effects of Levothyroxine on Lipoprotein in Patients with Subclinical Hypothyroidism 亚临床甲状腺功能减退患者血浆脂蛋白与左旋甲状腺素的关系探讨
Low initial dose of levothyroxine for treatment of congenital hypothyroidism 初始小剂量L-甲状腺素治疗先天性甲状腺功能低下症疗效研究
Effects of levothyroxine treatment on symptoms and serum lipids in the patients with subclinical hypothyroidism 左旋甲状腺素治疗对亚临床甲状腺功能减退患者血脂和症状影响
Matrix Metalloproteinases Changes in Rat Hypertrophic Myocardium Induced by Levothyroxine and the Effect of A New Endothelin Receptor Antagonist CPU-0213 左-甲状腺素诱导的大鼠肥大心肌中基质金属蛋白酶的变化及新内皮素受体拮抗剂CPU-0213的作用
Clinical observation of levothyroxine im primary nephrotic syndrome followed with hypothyroidism 左旋甲状腺素治疗原发性肾病综合征继发甲状腺激素降低的临床观察
Methods: 34 subclinical hypothyroidism patients were treated by low dose of levothyroxine, the serum lipids and the symptoms after treatment were compared with that before treatment. 方法:对34例亚临床甲状腺功能减退患者,给予小剂量左旋甲状腺素治疗,比较治疗前后患者的临床症状和血脂变化。
Clinical trial of domestic levothyroxine sodium 国产左旋甲状腺素钠临床试验研究
The result showed that the suppressive therapy with levothyroxine could efficiently and safely inhibit the growth of benign multiple thyroid nodules. 结果显示,L-T4抑制性治疗能有效和安全地抑制良性、多发性甲状腺结节的生长。
METHODS: 2 1 healthy male volunteers received a single oral doses of 600 μ g of levothyroxine sodium in three times cross-over clinical trial and their serum drug concentration were determined by Radioimmunoassay ( RIA). 方法:21名健康男性受试者参加了单剂量(600μg)三周期交叉试验并用放免分析法测定给药后不同时间点血清药物浓度。
Results Hypothyroid myopathy and polymyositis had similar symptoms of muscle dysfunction and elevation of serum muscle enzymes, but could be distinguished by thyroid function tests. Replacement therapy with levothyroxine was effective. 结果甲状腺功能减退性肌病与多发性肌炎在肌肉方面的表现相似,但甲状腺功能检查可以鉴别,左甲状腺素替代治疗有效。
Objective: To study the effect of thyroid hormone on the expression and distribution of Cx43 in canine hyperthyroid cardiomyopathy induced by Levothyroxine and to investigate the relationship between the remodeling of Cx43 and atrial tachyarrhythmia. 目的:研究左旋甲状腺素对犬心房肌连接蛋白Cx43表达的影响,探讨甲状腺功能亢进性心脏病(简称甲亢性心脏病)发生房颤的机制。
Levothyroxine sodium can effectively adjust the inadequate secretion of thyroid. 左甲状腺素钠片可以有效地调整甲状腺分泌不足。
The evaluation research of quality for levothyroxine sodium tablets provides the base for revision of the quality standard. 本文的评价实验研究为该品种质量标准的修订提供了依据。
But the instability of levothyroxine chemical structure, as well as the diversity of the prescription process, can lead to bioequivalence differences, which makes the quality in shelf life unstable, causing clinical therapeutic effect uncontrollable. 但是由于左甲状腺素化学结构的不稳定性,以及处方工艺的多样性,可导致制剂生物等效性差异,使货架期的质量不稳定造成临床治疗效果的不可控。