So people will try and get some sort of gene-based test to measure the expression-mutation of these kinases. 因此人们尝试着取得一些基因水平的测试蛋白激酶突变表达的方法。
Inhibiting BCR-ABL tyrosine kinases can impede the growing progress of tumors. 抑制BCR-ABL酪氨酸激酶可有效抑制肿瘤生长。
However, further studies have indicated that they are actually DNA-damage-response kinases, regulating more than just cell-cycle checkpoints. 进一步的研究表明它们事实上是DNA损伤-应答激酶,不仅仅是调控细胞周期的检查点。
Molecular basis of signal transduction mediated by calcium-dependent protein kinases ( CDPKs) in plants 钙依赖蛋白激酶(CDPKs)介导植物信号转导的分子基础
Both of those genes code for proteins called kinases, which regulate the processing of key cellular signals. 这些基因可编码调节细胞传导过程的激酶活性。
Kinases are protein switches that activate other proteins by adding a phosphate group to them via a process called phosphorylation. 激酶是蛋白开关,它们通过一个称为磷酸化的过程将磷酸基团结合到其他蛋白上并激活这些蛋白。
Function of Protein Kinases in Stress Signal Transduction in Plants MAPKs在植物逆境信号转导中的作用
Crosstalk Between Nitric Oxide, Ca~ ( 2+) and Protein Kinases in Plant Cells 植物细胞NO,Ca~(2+)和蛋白激酶的信号交叉
The epidermal growth factor receptor ( EGFR) family of receptor tyrosine kinases have close connection with the initiation, progression and prognosis of various malignancies. 表皮生长因子受体(EGFR)家族的受体酪氨酸激酶与多种恶性肿瘤的发生、发展及预后等密切相关。
Roles of Mitogen Activated Protein Kinases in Cerebral Ischemic Preconditioning: Comparison among ERK, JNK and p38 丝裂原激活的蛋白激酶在脑缺血预适应中的作用:ERK、JNK和p38作用的比较
This paper introduces the first, second and some new BCR-ABL tyrosine kinases inhibitors. 本文介绍了第一、二代以及新近开发的BCR-ABL酪氨酸激酶抑制剂。
The Roles of Spinal Protein Kinases in Bee Venom-induced Pathological Pain 脊髓源性蛋白激酶在蜜蜂毒诱致的病理性痛中的作用
The largest group of kinases are Protein kinases, which act on and modify the activity of specific proteins. 蛋白激酶是数量最多的一类激酶,作用和修饰特定蛋白的活性。
The study on expression of p38 mitogen-activated protein kinases in experimental colitis 实验性结肠炎p38丝裂原活化蛋白激酶表达的研究
But you wouldn't pick this up with an assay which only measured the kinases themselves. 不能因为是检测阵列而强调这一点,因为检测阵列仅测定蛋白激酶本身。
The tyrosine kinases expressed by BCR-ABL fusion gene can cause cell proliferation, adhesion and survival natural change, several kinds of tumors can be caused by it. BCR-ABL融合基因表达出的酪氨酸激酶能引起细胞增殖、黏附和生存性质的改变,导致多种肿瘤的产生。
Furthermore, we provide evidence that the CD36 scavenger receptor and downstream kinases are involved in SYN-mediated microglial activation. 此外,CD36受体和下游的激酶参与SYN介导的小神经胶质的活化。
Regulation of Protein Kinases on Signal Pathway in Breast Cancer Cell MCF-7 by Curcumin 姜黄素对乳腺癌MCF-7细胞信号传导通路相关蛋白激酶的调节作用
Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions. 摘要蛋白质酪氨酸在一系列细胞活动的信号转导途径中起著重要的作用。
Researchers at Monash University found that a group of enzymes known as protein tyrosine kinases ( PTKs) have a greater role than previously thought in the rate of growth and tumour change over time. 莫纳什大学的科研人员发现,随着疾病的发展,蛋白酪氨酸激酶(PTKs)这一酶家族在肿瘤的生长速度和变异方面比先前所了解的有着更广泛的作用。
Many cancer therapeutics, such as EGFR inhibitors, target proteins that are kinases& enzymes that initiate a cascade of signals that tell cells to reproduce. 许多癌症治疗方法,如EGFR抑制因子,靶向激酶-酶蛋白,而这些蛋白能启动新号级联反应而使细胞繁殖。
Hemorrhage and resuscitation ( H/ R) leads to phosphorylation of mitogen-activated stress kinases, an event that is associated with organ damage. 出血和复苏后导致丝裂原活化的应激激酶的磷酸化,这是一个与器官损害有关的事件。
Effect of Receptor Protein-tyrosine Kinases in Tumor Angiogenesis 受体酪氨酸激酶在肿瘤血管新生中的作用
Anticancer therapies targeting HER2 have shown promise and become a focus, including monoclonal antibody, tyrosine kinases inhibitor, tumor vaccine, fusion protein. 包括单克隆抗体、酪氨酸激酶抑制剂、融合蛋白、瘤苗在内,以HER2为靶点的抗肿瘤治疗研究成为热点,并显示出广阔的应用前景。
Stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate. 司他夫定通过细胞激酶磷酸化,形成司他夫定的三磷酸盐而发挥抗病毒活性。
Expression of phosphorylated cyclin-dependent kinases in neurons after focal cerebral ischemia in rats 磷酸化细胞周期素依赖性激酶在局灶性脑缺血大鼠神经细胞中的表达