The volume of Neuron decrease, Cytoplasm's stain is dark, karyopyknosis are observed. 病变神经元体积缩小,胞质着色深,核固缩,神经元周围出现空隙。
Morphological changes including chromatic agglutination, karyopyknosis, and nuclear fragmentation could be observed in some of the cells under inverted microscope. 倒置显微镜下可观察到部分凋亡细胞出现染色质凝集、核固缩、核碎裂等形态学改变。
Results In the infected model group, there were obvious swelling, karyopyknosis and destruction of the structure in the brain cells, as well as myelin sheath solution and vacuolar degeneration in the mitochondrion and crest were destroyed. 结果电镜下感染模型组小鼠脑细胞胞浆水肿明显.核仁固缩,核内结构破坏,多数线粒体呈空泡样改变,核仁内可见病毒颗粒内脊破坏、髓鞘严重松解、破坏。
Results: The grub extract significantly inhibited the proliferation of gastric cancer cells in vitro, morphologic changes of apoptosis with chromatin margination, karyopyknosis, karyorrhexis, apoptotic body were found by the light scope. 结果:光镜结果表明,蛴螬(终浓度为4mg/ml)作用于MGC-803胃癌细胞24h后,可见胞核固缩、胞核碎裂、凋亡小体形成等凋亡形态学变化;
Results: Aluminum overload elevated MAO-B activity, caused karyopyknosis and loss of neurons in CA1 area of hippocampi, in dose-and time-dependent manners. 结果:铝过负荷致小鼠脑内MAO-B活力显著升高和CA1区出现明显神经元丢失及核固缩;
Changes of the ultrastructure: The neurons in the cortex of SHR with the ascending of blood pressure, appeared karyopyknosis, mitochondria swollen, crista lost, the membranes of pre-synaptic and post-synaptic were not clear and the synaptic space was disappeared. 超微结构的改变:SHR大脑皮质内神经元随着血压的升高出现核固缩、线粒体肿胀、嵴消失以及突触前后膜肿胀、突触间隙消失等改变。
Swelling and pyknosis in cytoplasm and karyopyknosis in some cells were found. 胞质肿胀疏松,有的细胞出现核固缩。
Histopathological changes of cerebrum: After one week and 3 months, the neurons of sample rats show derangement, karyopyknosis, gliacyte proliferation. 脑组织病理学改变:术后一周和术后3月,模型鼠脑组织均可以见到神经元细胞较对照组排列紊乱,细胞核固缩,胶质细胞增生;
While osteocytes were found in bone lacuna of transplanted bone in experimental group all along, Karyopyknosis. 而实验组术后骨陷窝内始终有骨细胞充填。
Under microscope, the structure of cancer cell appeared to be more porous 9 hours later interventional treatment and karyopyknosis was found 24 hours later, then we found obvious necrosis after 48 hours. Paramorphia of the relic cancer cells were found in 16-21d. 介入治疗后9h在光镜下可见癌细胞出现结构松散,24h癌细胞出现核固缩,48h见明显坏死,16~21d残存的癌细胞出现形态异常。
The early apoptotic change under transmission electron microscope was mainly the structural changes of mitochondria, then the classical ultrastructural feature of apoptosis, such as karyopyknosis, chromatic agglutination adjacent to the nuclear membrane and apoptotic body were found in late stage. 透射电镜观察显示,凋亡早期主要是线粒体结构的改变,后期则出现典型的凋亡征象,如核固缩、染色质凝集靠近核膜和凋亡小体形成。
Results: After being incubated with burn serum which obtained from patient on 1d preoperation, the HUVECs were deformed showing shrinkage of the cells and formation of intercellular space, and small vacuoles appeared in cytoplasm with karyopyknosis. 结果显示,一次性大面积切痂术前1d烧伤血清可使体外培养的内皮细胞脱落,细胞变形,细胞收缩间隙增大,胞浆出现空泡,核固缩。
Observation by light and electron microscope show the cell start to have morphologic change from an irregular shape to a round shape, the volume was reduced significantly after treating for 4-6 hours with the BR and karyopyknosis apoptotic bodies were found after 12 hours. 光镜、电镜观察结果,各药物组加药后4~6小时开始发生细胞形态学改变,由不规则形变为圆形,体积明显变小,12小时后可见细胞核固缩、凋亡小体形成等。
TEM revealed expansion of paranucleus space and karyopyknosis of the bipolar cells, the swelling of nerve fibers and disappearance of the synapses in the inner plexiform layer, the vacuolation and disappearance of microvilli of the pigment epithelium cells. 电镜显示双极细胞核周池扩张、核固缩,内丛状层神经突起肿胀、突触消失,色素上皮细胞空泡化改变、微绒毛消失。
At 48 hours after culture, cytotoxicity was detected out in the positive control group; cells in the oxidation and blank control groups were normal and grew well. A few of cells in the non-oxidation group showed karyopyknosis. 2. 培养48h,阳性对照组大量细胞核固缩;氧化组、空白对照组细胞形态正常,生长旺盛;非氧化组少量细胞核固缩。
Prefrontal cortex of ketamine group exhibited karyopyknosis of partial pyramidal cells, as well as cytoplasmic acidophilic changes. 3. 氯胺酮组前额皮质区与对照组相比,可见部分锥体细胞核固缩,胞浆嗜酸性变。