This essay explained the potential health impacts of flavonoid intake through DNA intercalators principle. 文章通过DNA嵌入剂原理来解释过度摄入黄酮类物质的潜在危害。
The intercalators influence the physiologic function through the insertion of planar aromatic rings between DNA base pairs, which results in a conformational change of DNA. DNA嵌插剂可通过平面芳香环系统插入DNA碱基对之间,造成DNA构象变化,影响其生理功能,达到抗肿瘤效果。
Several intercalators are used for the treatment of ovarian and breast cancer as well as acute leukemia, while many others are in different phases of clinical trials. 目前数个DNA嵌插剂开发用于卵巢癌、乳腺癌及急性白血病等肿瘤的治疗,处于各临床研发阶段的品种不少。
DNA intercalators have found important uses in the study of interaction between DNA and small molecules and anticancer drug design. DNA嵌入剂在研究小分子与DNA的相互作用以及肿瘤治疗中都有着极其重要的用途。
It modified the organized montmorillonite by using of three different kinds of intercalators, and prepared nylon 6/ montmorillonite nanocomposites by melt blending nylon 6 respectively. It studied the heat-distortion temperature ( HDT) and mechanical properties of the nanocomposites. 用3种不同的插层剂有机化蒙脱土,并分别与尼龙6熔融共混制得了尼龙6/蒙脱土纳米复合材料,对热变形温度(HDT)和力学性能进行了研究。
It is reported that xanthone could act efficient DNA intercalators and topoisomerase inhibitors, displaying interesting anticancer activity. 研究报道双苯吡喃酮类化合物可以作为有效的DNA嵌入剂和拓扑异构酶抑制剂,起到抑制肿瘤增值的作用。