The major physical sign included: disappearance of pupil direct and indirect light reflex, ophthalmoplegia externa, nystagmus, ataxia, hypesthesia, peripheral facial paralysis, and weak or disappeared tendons. 主要神经系统体征:瞳孔直接及间接对光放射消失,双侧眼外肌麻痹,水平眼震,周围性面瘫,共济失调,深、浅感觉减退,腱反射减弱或消失。