hypermethylation
英
美
网络 高甲基化; 过甲基化; 甲基化; 高度甲基化; 超甲基化
双语例句
- The Study on the Relationship between Protein Expression and Promoter Hypermethylation of Estrogen Receptor and Progression in Women Sporadic Breast Carcinomas
雌激素受体蛋白表达和启动子甲基化与女性散发性乳腺癌发生发展的相关性研究 - Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene.
目前研究表明ARF基因在肿瘤发生过程中可有起一定的作用，ARF基因功能的失活可能主要通过该基因启动子高度甲基化。 - Both global hypomethylation and hypermethylation "coexist in all tumors and can contribute to tumor development and progression through different mechanisms," he said.
广泛低甲基化和高甲基化“共存于所有肿瘤且以不同的机制导致肿瘤的发展和恶化，”他说。 - 14-3-3 σ Hypermethylation and Its Relationship with Protein Expression in Sporadic Breast Carcinogenesis
散发性乳腺癌细胞14-3-3σ异常甲基化及其蛋白表达的关系 - The Study of Hypermethylation Related Genes in Endometrial Cancer Cells
DNA甲基化相关基因在子宫内膜癌细胞中的研究 - Hypermethylation status of blu gene in nasopharyngeal lymphoma
blu基因在鼻咽部淋巴瘤的甲基化状态研究 - Hypermethylation Leads to Down-regulated 14-3-3 Sigma Expression in Nasopharyngeal Carcinoma Tissues
基因甲基化导致鼻咽癌组织14-3-3σ表达下调 - The significance of promoter hypermethylation of Cyclin D2 and ER-α in the early diagnosis of breast cancer
cyClinD2及ER-α基因DNA甲基化在乳腺癌早期诊断中的意义 - Detection of Promoter Hypermethylation of WIF-1 Gene by Nested Methylation Specific Polymerase Chain Reaction in Lung Cancer Patients
巢式甲基化特异性PCR检测肺癌病人WIF-1基因启动子区异常甲基化 - Objective To investigate the hypermethylation status of blu gene promoter in nasopharyngeal NK/ T cell lymphoma and its role in the tumorigenesis and molecular diagnosis of this lymphoma.
目的探讨鼻咽部淋巴瘤blu基因启动子的高度甲基化在肿瘤发生中的作用及在分子病理诊断中的应用价值。 - AIM: To investigate the hypermethylation of the BLU and ARF promoter in nasal NK/ T cell lymphoma from nasopharyngeal mucosa and its roles in tumor genesis and molecular pathological diagnosis.
目的：检测BLU与ARF基因启动子在鼻NK/T细胞淋巴瘤中的甲基化状态，探讨其在肿瘤发生中的作用与分子病理诊断中的应用价值。 - Objective To study the effect of operative region hypermethylation gene in human malignant hematopoietic tumors.
目的探索特定基因操纵区CpG岛高甲基化对人类造血系统恶性肿瘤的作用。 - Comparison of hypermethylation of BLU and ARF genes in nasal NK/ T cell lymphomas
BLU和ARF基因在鼻NK/T细胞淋巴瘤中的甲基化状态比较 - In human cancer cells, DNA methylation mainly refers to the CpG island hypermethylation of tumor suppressor gene.
在肿瘤细胞中DNA甲基化主要指抑癌基因CpG岛的异常甲基化，这种异常甲基化抑制基因转录，使抑癌基因丧失抑癌作用。 - The CT gene hypermethylation changed partly along with induction differentiation of leukemia cells in vitro.
观察到CT基因高甲基化状态随着白血病细胞形态和功能上的成熟而部分改变。 - Hypermethylation of promoter is the key mechanism of tumor suppressor gene inactivation.
基因启动子区域异常甲基化是肿瘤抑制基因失活的一个关键机制，与肿瘤每一步形成有关的基因也能靠这种机制失活。 - Objective To study the relationship between calcitonin ( CT) gene hypermethylation and the prognosis of malignant hematological disorders.
1目的探讨降钙素（CT）基因高度甲基化与恶性血液病预后的关系。 - Objective To explore the relationship between myeloproliferative disorders ( MPD) and calcitonin ( CT) gene hypermethylation.
目的探讨骨髓增生性疾病（MPD）与降钙素（CT）基因高度甲基化的关系。 - Hypermethylation of CpG island in promoter region of DNA repair gene MGMT in esophageal carcinoma
食管癌中DNA修复基因MGMT启动子区CpG岛过甲基化研究 - When the hypermethylation is demethylated, the mRNA expression gets a corresponding increase.
当其超甲基化解除后，MT3基因的mRNA表达水平也会相应升高。 - Methods Promoter hypermethylation and mRNA expression of DAPK gene were detected by methylation-specific PCR, RT-PCR and gene sequencing.
方法采用MSP和RTPCR法分析喉部正常黏膜、喉癌及相应癌旁组织中DAPK基因启动子区过甲基化及其mRNA表达状况。 - CpG island hypermethylation is emerging as an important mechanism for inactivation of tumor suppressor genes in the carcinogenesis.
抑癌基因启动子区CpG岛高甲基化导致其表达沉寂，是癌症发生中的一个重要机制。 - Objective To investigate the correlation between gene hypermethylation of multiple tumor suppressor genes in CpG islands of promoter and lung cancer.
目的研究多个抑癌基因启动子CpG岛高甲基化与肺癌的关系。 - DNA methylation is an important means of regulating transcription of genes, the researches found that hypermethylation of tumor suppressor gene could induce gene silencing and closed related with hematopoietic tumors.
DNA甲基化是调控基因转录表达的一种重要手段，研究发现，抑癌基因启动子区高甲基化致基因沉默与造血系统肿瘤的发生密切相关。 - The gene promoter inactivation occurred after hypermethylation, leading to disorder of cell cycle and cancerous.
该基因启动子发生甲基化之后会引起基因的失活，导致细胞周期紊乱而发生癌变。