If the score reaches a certain level, the strongest lord of the HRE will become Counter King and the leader of the opposition. 如果分数到达一定水平,HRE内最强的领主会另立为帝,成为反对派的领袖。
Aim: To observe change of binding activity of HIF-1 with erythropoietin ( EPO) hypoxia response element ( HRE) in the hippocampus of mice preconditioned to hypoxia and explore relationship between the changes and the preconditioning. 目的:观察低氧预适应对小鼠海马组织HIF-1与EPO的低氧应答元件(HRE)结合活性的变化,探讨这种变化与低氧预适应形成的关系。
The effect of hypoxia preconditioning no binding activity of HIF-1 on the HRE with EPO in the hippocampus of mice 低氧预适应对小鼠海马组织HIF-1与EPO低氧应答元件结合活性的影响
Two pair primers was designed and synthesized according to reported gene sequences of the hypoxia responsive element ( HER) and human a-fetoprotein ( AFP) core promoter ( AF0.3). 根据文献报道的缺氧应答元件(HRE)和人甲胎蛋白(AFP)核心启动子(AF0.3)基因序列,设计并合成2对引物,采用PCR方法从肝癌细胞基因组DNA中扩增获得大小分别约为。
Conclusion HIF-1 binding site of HRE may play an important role in the hypoxia-induced GLUT-1 mRNA expression in rat liver cells. 结论HRE中的HIF1结合位点在GLUT1mRNA的缺氧诱导中起重要的作用。
The classical mechanism for nuclear receptors to regulate gene expression is to bind the hormone response element ( HRE) on the target gene in the presence of their ligands. 核受体家族的经典作用机制是在其配基存在下结合在靶基因的应答元件上,从而在转录水平上调节基因的表达。
Methods: Hypoxia response element ( HRE) oligonucleotides derived from hypoxia response genes were synthesized and linked with CMV promoter to construct hypoxia response promoters. 方法:合成源于各种缺氧应答基因的缺氧应答元件(HRE)寡核苷酸序列,与CMV启动子连接组合,测定荧光素酶的相对活性以确定缺氧转录活性。
CONCLUSION: Two expression vectors harboring PNP gene are novel effective vectors for human hepatocellular car-cinoma gene therapy, and p [ HRE] AF/ PNP is a target-expressing vector in AFP positive, especially in AFP negative hepatocellular carcinoma cells. 结论:两PNP基因表达载体是肝癌基因治疗中新型、高效的治疗载体,p[HRE]AF/PNP还实现了在AFP阳性,尤其是AFP阴性肝癌细胞中的靶向性表达。
A hyperrectangle rules extraction ( HRE) algorithm is proposed to extract rules from trained SVM. 提出了一种基于SVM的超矩形规则提取算法HRE。
Hypoxia-inducible factor-1 ( HIF-1) which is a DNA binding protein produced under hypoxia condition increase transcription of glycolysis metabolic enzymes combining with hypoxia reacted element, and make the body adapt to the low oxygen environment. 低氧诱导因子-1(Hypoxia-induciblefactor-1,HIF-1)是低氧状态下产生的一种DNA结合蛋白,与低氧反应元件(HRE)结合,诱导糖酵解代谢关键酶等转录增加,使机体适应低氧环境。