Cadherin-11 is a single-chain integral membrane glycoprotein, which mediates calcium-dependent cell cell adhesion by homophilic manner. 钙粘附蛋白-11(Cadherin-11)属于Ⅱ型钙粘附蛋白,是一种钙离子依赖性介导嗜同性细胞-细胞间粘附的跨膜糖蛋白。
E-cadherin mediated cell-cell homophilic adhesion, which is linked to the cytoskeleton via catenins. 粘附分子E-cadherin通过catenins与细胞骨架相连介导细胞同质粘附作用。
Ep-CAM is broadly expressed on normal epithelials mediating the homophilic adhension as well as some neoplasm with epithelial origin, expression degree of which is closely related to tumor differentiation. Ep-CAM既广泛表达于正常上皮,介导同型腺上皮的黏附功能,其表达程度与肿瘤的分化密切相关。
Objective To study the expression of homophilic cell adhesion molecules E-Cadherins ( E9 and Uvomorulin) for elucidating the pathogenesis of molecular basis in Ming's classification of gastric carcinoma according to its growth pattern. 目的研究同种亲和性钙离子依赖细胞粘附分子E-Cadherins(E9和Uvomoru-lin)在不同生长方式胃癌中的表达。