hnpcc
英
美
网络 遗传性非息肉病性结直肠癌; 遗传性非息肉病性大肠癌; 遗传性非息肉性结直肠癌; 遗传性非息肉性结肠癌; 遗传性非息肉病性结肠癌
双语例句
- Objective To understand the hereditary susceptibility and theoccurrence pattern of hereditary nonpolyposis colorectal cancer ( HNPCC) in members of the families with a clear family history.
目的提高对遗传性非息肉病性大肠癌（HNPCC）本质的认识，了解其家庭易感性及聚集倾向。 - Blood tests are now available to test for FAP, AFAP, MYH, and HNPCC hereditary colon cancer syndromes.
血液化验，现已是测定FAP，AFAP，MYH，与HNPCC等遗传性大肠癌综合征的方法。 - To improve the recognition of the hereditary nonpolyposis colorectal cancer ( HNPCC) in its clinical diagnosis.
提高对遗传性非息肉病性大肠癌（HNPCC）临床诊断的认识。 - Objective To investigate the phenotype feature of hereditary nonpolyposis colorectal cancer ( HNPCC) in the population of middle area in China and to provide scientific basis for formulating the diagnosis criteria of HNPCC suitable for Chinese.
目的探讨中原地区遗传性非息肉病性大肠癌（HNPCC）的表型特征，为制订适合我国国情的HNPCC遴选标准提供依据。 - Objective: To analyses the molecular and clinical pathology features of hereditary non-polyposis colorectal cancer ( HNPCC).
目的：对遗传性非息肉病性结直肠癌的分子遗传学和临床病理特征进行研究。 - Methods PCR based in vitro synthesized protein test ( IVSP) assay and sequencing analysis were used to confirm somatic mutations of whole APC gene in 19 HNPCC patients.
方法采用体外蛋白合成试验和序列分析确定19例HNPCC病例APC体细胞突变。 - Objective: To characterize the clinical features of Chinese HNPCC families and to screen the mutations of a poly ( A) 8 tract in M3 cholinergic receptor gene in these families.
目的：分析中国人遗传性非息肉病性大肠癌（HNPCC）家系的临床特征并检测这些家系中M3胆碱能受体基因（A）8区的突变情况。 - Hereditary nonpolyposis colorectal cancer ( HNPCC) was diagnosed by any of Amsterdam criteria, Amsterdam criteria ⅱ and Japanese criteria of HNPCC.
家族符合Amsterdam标准、Amsterdam标准Ⅱ和日本标准等中任何&个者均可诊断为遗传性非息肉病性结直肠癌（HNPCC）。 - The clinical phenotypes are the most important indication to find HNPCC.
临床表型特征仍是发现HNPCC家系的首要指征。 - Methods: Four families of HNPCC and medical literature were analyzed.
方法：复习文献并结合本组四个家族的临床资料进行总结分析。 - Conclusion: M3 cholinergic receptor gene might have little relation with HNPCC in Chinese population.
结论：M3胆碱能受体基因与中国人群中HPNCC的发病可能无密切关系。 - We can consider part of serum amino acids and Fe? Ca as indirect indexes for HNPCC family.
结论：血清中的部分游离氨基酸及Fe、Ca可作为HNPCC家族监测的间接指标。 - It is necessary to detect the large intragenic MMR genes deletions in the molecular detection of HNPCC.
在分子遗传学检测中有必要开展MMR基因大片段缺失的检测。 - Conclusions ( 1) HNPCC is of autosomal dominant inheritance ( AD).
结论（1）该家族呈常染色体显性遗传； - So it is necessary to set up criteria for diagnosis of HNPCC in Chinese.
建立中国人的HNPCC诊断标准是必要的。 - Objective To investigate the clinicopathological and molecular genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer ( HNPCC) pedigrees.
目的了解国人遗传性非息肉病性结直肠癌（HNPCC）的临床病理及分子遗传学特征。 - Objective To investigate the clinical features of hereditary nonpolyposis colorectal cancer ( HNPCC) so as to provide evidence for its targeted screening and early diagnosis.
目的探讨遗传性非息肉病性大肠癌（HNPCC）的临床特征，为大肠癌的靶向筛检、早期诊断提供依据。 - Method 32 families with HNPCC were registered and followed up.
方法对随访登记的32家系进行随访和回顾。 - Objective To analyze the mutational features of adenomatous polyposis coli ( APC) gene and to explore the effect of mismatch repair ( MMR) deficiency on its mutations in hereditary non polyposis colorectal cancers ( HNPCC).
目的分析遗传性非腺瘤病性结直肠癌（hereditarynon-polyposiscolorectalcancers，HN-PCC）结肠腺瘤病（adenomatouspolyposiscoli，APC）基因突变的特点及错配修复缺陷对其影响。 - Objective To study the clinicopathological and molecular genetic characteristics of hereditary nonpolyposis colorectal cancer ( HNPCC), to enable the early diagnosis and to evaluate the treatment.
目的探讨总结遗传性非息肉病性结直肠癌（hereditarynonpolyposiscolorectalcancer，HNPCC）的临床和分子生物学特征，提高临床诊断和治疗水平。 - The sex-specific difference in incidence of HNPCC has been attributed to estrogen.
这种HNPCC发病率上的性别差异可能与雌激素有关。 - The genetic basis of HNPCC is MMR gene mutation.
HNPCC的遗传学基础为MMR基因突变。 - Immunohistochemical staining and microsatellite analysis are commonly used as the first diagnostic screening test for HNPCC.
免疫组织化学（IHC）染色和微卫星分析（MSI）常用于HNPCC最初的诊断性筛查。 - The most effective treatment of HNPCC is endoscopic and surgical removal of the tumor. If the primary and recurrent tumor can be detected earlier and radical surgery can be carried out, which can significantly improve the prognosis.
HNPCC最有效的治疗手段是内镜下或外科手术切除肿瘤，如果能早期发现原发和复发肿瘤，并及时治疗，可以明显改善预后。 - MSI detection of skin lesions is a easier method, it can be used as the basis of non-invasive screening of HNPCC or Muir-Torre syndrome and is a valuable method to determine the defects of the MMR genes and look for new MMR genes.
对皮肽病变进行MSI的检测，方法较易，可作为HNPCC或Muir-Torre综合征非侵入性筛查的基础，是确定MMR基因的缺陷和寻找新的MMR基因的一种有价值的方法。 - It has been reported that in HNPCC families, the incidence of colorectal cancer ( CRC) is higher in male mutation carriers than in female, which was found similar in Chinese HNPCC families.
既往研究表明，在HNPCC家族中，男性突变携带者患结直肠癌的风险高于女性突变携带者；在中国人HNPCC家系中也发现了类似情况。 - Now, many countries and territories have established the clinical diagnostic criteria for HNPCC, such as Amsterdam Criteria and Bethesda Guidelines.
目前，世界许多国家和地区都制定了一定的HNPCCI临床诊断标准，如Amsterdam标准，Bethesda指导纲要等。