Hemiatrophy-Hemiparkinsonism Syndrome: a report of 6 cases and Review of the literature 偏侧萎缩-偏侧帕金森综合征&6例报道并文献复习
The Study of Hemiparkinsonism in Primate after Unilateral Internal Carotid Artery Infusion of MPTP 单侧颈内动脉注入MPTP建立偏侧帕金森病灵长类模型的研究
Conclusion The monkey model of hemiparkinsonism could be induced by unilateral internal carotid artery infusion of MPTP. As MPTP could be infused into the internal carotid artery easily and completely, common carotid artery cannulation should be recommended in PD model induction of rhesus monkey. 结论与颈外动脉夹闭颈总动脉注射相比,颈总动脉插管颈内动脉注射MPTP制作偏侧恒河猴帕金森病模型更为简单有效。海绵窦段颈内动脉瘤颈内动脉狭窄是常见的。
Evaluation on the Hemiparkinsonism Monkey Model 偏侧帕金森病猴模型的评价
Objective To investigate a stable skill for preparing the hemiparkinsonism rhesus monkey model by unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine ( MPTP). 目的探讨经颈内动脉注射MPTP制作偏侧恒河猴帕金森病模型的稳定技术和方法。
Marked depletion of DA, DOPAC and HVA and significant elevation of DOPAC/ DA and HVA/ DA ratios were found in the caudate nucleus, putamen and substantia nigra of the monkeys with generalized parkinsonism and hemiparkinsonism ( lesioned side). 结果发现:(1)6只双侧和4只偏侧帕金森病猴模型的尾状核、壳核和黑质DA及其代谢产物显著降低,DOPAC/DA和HVA/DA比值明显增高;