Objective To approach the preventative effect and mechanism of halofuginone for liver cirrhosis in rats. 目的探讨卤夫酮预防大鼠肝硬化的效果和机制。
Synthesis of Anticoccidial Drug Halofuginone Intermediate of 7-Bromo-6-chloro-4 ( 3H)-quinazolinone 抗球虫药常山酮中间体7-溴-6-氯-4(3H)-喹唑啉酮的合成
Study on the Synthesis of Halofuginone ⅰ. Preparation of Intermediate 7-bromo-6-chloro-4 ( 3H)-quinazolinone 禽兔抗球虫药常山酮的合成研究&Ⅰ.中间体6-氯-7-溴-4(3H)喹唑啉酮的制备
Determination of Halofuginone Residues in Sturgeon Muscle by HPLC 鲟鱼肌肉中氢溴酸常山酮残留检测的高效液相色谱法
Experimental Study on the Preventative Effect of Halofuginone for Liver Cirrhosis in Rats 卤夫酮预防大鼠肝硬化的实验研究
In this study, the ELISA method vs HPLC method for the determination of the halofuginone in chicken liver and muscle were compared. 本研究对ELISA方法和HPLC方法进行了比较。ELISA方法和HPLC方法测定鸡肝脏和肌肉组织中常山酮残留有良好的相关性。
Halofuginone could inhibit the synthesis of type ⅰ collagen of fibroblasts derived from human scar in a concentration-dependent manner, but had no effects on synthesis of type ⅲ collagen. 常山酮可抑制成纤维细胞合成Ⅰ型胶原,且随浓度增加作用增强,但不影响Ⅲ型胶原的合成。
It is proposed that halofuginone can destroy the oocyst wall. 根据结果推测,氢溴酸常山酮可能对卵囊壁的结构具有破坏作用。
The coefficients of correlation for the detection of halofuginone in chicken liver and muscle by two methods were 0.9760 and 0.9344, respectively. 在添加回收试验中,两种方法在鸡肝脏和肌肉组织中测得常山酮的实测值的相关系数分别为0.9760和0.9344。
7-bromo-6-chloro-4 ( 3H)-quinazolinone is an important intermediate of anticoccidial drug halofuginone, which was prepared from nitrobenzene by bromination, reduction, condensation, cyclization and so on. The overall yield of the seven-step is 60%. 研究以硝基苯为起始原料,经过溴化、还原、缩合、环化等七步反应,合成了7-溴-6-氯-4(3H)-喹唑啉酮,总收率为60%。
For the reasons aforementioned, we carried series of experiments to research the action mechanism of halofuginone hydrobromide against Eimeria tenella. 1. 因此,我们对氢溴酸常山酮抗柔嫩艾美耳球虫的作用开展了研究。