As an intermediate for preparing ethyl vanillin derived from glyoxylic acid, 3-ethoxy-4-hydroxymandelic acid ( EHMA) is synthesized based on condensation of guaethol and glyoxylic acid in alkaline aqueous solution. 以邻羟基苯乙醚(乙基愈创木酚)和乙醛酸为原料,在碱性条件下发生缩合反应,合成了3乙氧基4羟基扁桃酸,此物质是以乙醛酸法制备乙基香兰素的中间体。