The advances in the synthesis of O-and N-linked glycopeptides based on the solid-phase method are reviewed. 本文对O-连接和N-连接糖肽固相合成的研究进展进行了综述。
Progress and Clinical Evaluation of Glycopeptides and Cyclic Lipopeptide Antibiotics 糖肽和环脂肽抗生素的进展与临床评价
Purification of Complex N-Glycan and Synthesis of Glycopeptides 天然复杂型N-糖苷分离与糖肽的酶法合成
The glycopeptides did not show any direct toxic effect on the cancer cells. 糖肽还可减慢皮下接种的癌细胞的生长速度,但对癌细胞并无直接毒性作用。
Enterococcus faecium displayed high-level resistance against antibiotics in addition to glycopeptides. 屎肠球菌对除糖肽类抗生素以外的所有临床常用抗菌药物显示高水平耐药。
The effects of laminin glycopeptides on murine macrophage functions 层粘连蛋白总糖肽对小鼠巨噬细胞功能的影响
Glycopeptides are the first choice for the treatment of MRSA infections. MRSA感染首选糖肽类抗生素治疗。
Studies on Antitumor Activity of the Glycopeptides from Pig Red Cell Membranes 猪红细胞膜糖肽的抗肿瘤作用
Objective: This study was to probe into the antimetastasis mechanism of pig red cell membrane glycopeptides ( PRCMG). 目的:探讨猪红细胞膜糖肽抗肿瘤转移的作用机制。
When the products are fully water-soluble, such as antibiotics, sugars, glycopeptides, etc, the synthesis has to be carried out in aqueous medium. In this case the use of aqueous two-phase systems could be a suitable option for continuous extraction of the products. 对于水溶性产品,如抗生素、糖、糖肽等的合成,需在水相中进行,此处利用双水相系统有其明显优势。
In addition, the relative abundance of heterogeneous glycopeptides was quantified. 此外,还对糖型不均一造成的几种糖肽进行了相对定量。
Glycopeptides in Soy Protein Hydrolysates and Their Effects on Proliferation of Murine Splenocytes 大豆蛋白酶解产物中的糖肽及其对小鼠脾细胞增殖效果的研究
The recognition and attachment of murine Lewis lung carcinoma cells, mouse S180-V sarcoma cells and human pulmonary giant carcinoma cells to laminin substrate were markedly inhibited by the glycopeptides. 它有明显地抑制小鼠Lewis肺癌细胞,S180肉瘤细胞及人巨细胞肺癌细胞与层粘连蛋白(Laminin,LN)基质粘着的作用;
Characterization of binding property to hCG receptor and inhibition effect of ovalbumin glycopeptides hCG受体的结合特性及卵清蛋白的抑制作用
Isolation and Identification of Glycopeptides in Soy Protein Hydrolysate β-伴大豆球蛋白水解产物中糖肽的分离和鉴定
Recent Development in the Syntheses of Glycopeptides 糖肽合成的新进展
By exploring the synthetic methodology of glycopeptides, we established the synthesis conditions of protection, coupling and deprotection in solution-phase combinatorial synthesis. 对糖肽类化合物合成进行了方法学研究,摸索出糖肽类化合物液相组合合成的保护条件、缩合条件和脱保护条件,确定了糖肽类化合物液相组合合成的通用性方法。
The glycopeptides were fractionated into three fractions on Con A-Sepharose CL-4B affinity chromatography column. 进一步经conA-SepharoseCL-4B亲和层析将总糖肽分为三个部分。
The effects of pig red cell membrane glycopeptides on tumor blood metastasis 猪红细胞膜糖肽抑制肿瘤的血行转移
Inhibition of ovalbumin glycopeptides on the hCG signal transduction system 卵清蛋白糖肽对hCG信号转导系统的抑制作用
The resistance of MRSA is very severer, which can be treated effectively only by Glycopeptides antibiotics. MRSA的耐药性非常严重,万古霉素等糖肽类抗生素是唯一有效的抗菌药物。
All of the isolates were sensitive to Penicillins, Fluoroquinolones, Rifampicin, Glycopeptides, and Nitrofurans. 虽然各菌株耐药谱不同,但各菌株均对青霉素类、氟喹诺酮类、利福平、糖肽类、硝基呋喃类敏感。
The characteristics of glycan structure determine that they do not have UV absorption, and have lower response in the mass spectrometry than peptides. So the derivatization of glycan or enrichment of glycopeptides before MS analysis should be carried on in the analysis of glycosylation. 糖链结构本身的特点决定了其没有紫外吸收,在质谱中的响应信号强度远不如肽段。
MRSA clinical isolates are typically multidrug resistant and could only be treated with glycopeptides such as vancomycin. MRSA临床分离株大多是多重耐药,仅对糖肽类抗生素如万古霉素敏感。
Compared with SGP that bears six amino acids, SG the complex-type oligosaccharide linked to a sole Asn, is easy to protect and modify chemically. The protected and/ or modified SG can be a substrate for solid-phase synthesis of glycopeptides with desired sequences. SG是只带有Asn的复杂型寡糖,相比带有6个氨基酸的SGP来说,更容易用化学法保护、修饰,保护修饰后的SG可作为底物,以固相合成法合成具有所需肽链序列的糖肽。