Result: Only at an excessively high dose can the medicines raise the erythrocytic osmotic fragilitas of G6PD deficiency in rats. 结果:G6PD缺陷大鼠红细胞渗透脆性仅在超大剂量给药时才有所增高。
The fragilitas lowers depending largely on the medicine in combination, dosage and proportion. 脆性降低程度与配伍药物、剂量、比例有关。
Conclusion: Focus on the erythrocytic osmotic fragilitas, at a general dose, Huanglian can not cause hemolysis. 结论:以红细胞渗透脆性为指标,一般黄连剂量尚不致引起溶血。
Objective: To study the influence of common combination of Huanglian ( Coptis chinensis) on the erythrocytic osmotic fragilitas of glucose 6 phosphate dehydrogenase ( G6PD) deficiency in rats. 目的:研究常用黄连配伍对G6PD缺陷大鼠红细胞渗透脆性的影响。
Method: Huanglian decoction and berberine solution are applied to the erythrocytes of G6PD deficiency in rats through external and oral administration and the erythrocytic osmotic fragilitas is measured. 方法:将黄连煎液和小檗碱溶液通过体内、外给药途径,应用于G6PD缺陷大鼠,检测其红细胞渗透脆性的变化。