In spite of this, the liPid Perxidation might not be the unique factor in the fibrogenesis due to quartz. 但在石英引致的肺纤维化过程中,脂质过氧化反应恐不是石英致纤维化的唯一因素。
Objective To study the mechanism of liver fibrogenesis and to find new non-invasive biomarkers. 目的研究肝纤维化的发生机制,寻找新的与肝纤维化相关的生物学标志物。
HC may induce fibrogenesis directly by hepatic stellate cell activation or indirectly by promoting oxidative stress and apoptosis of infected cells. 慢性丙型肝炎可能通过肝脏星形胶质细胞的活化、或者间接通过促进氧化应激和受感染细胞的凋亡,直接诱导纤维形成。
Differentiation of bone marrow stem cells in rat hepatic fibrogenesis environment 骨髓干细胞在大鼠肝纤维化形成环境中的分化
Objective To investigate the effect of Cordyceps sinensis ( CS) on pancreatic islet B cells of experimental hepatic fibrogenesis rats. 目的探讨应用虫草菌丝抗肝纤维化时对大鼠胰岛β细胞功能的影响。
AIMS: To observe effect of leptin on liver fibrogenesis, relationship between leptin levels and severity of liver fibrosis clue to chronic hepatitis B, and effects of lamivudine therapy on leptin expression. 目的:观察瘦素在慢性乙型病毒肝炎肝纤维化发生、发展中的作用及其与肝纤维化程度的关系。观察拉米夫定对慢性乙型肝炎患者瘦素表达的影响。
In vivo study of the relationship between extracellular signal-regulated kinase_1 and hepatic stellate cell proliferation during hepatic fibrogenesis 细胞外信号调节激酶1与肝星状细胞增殖关系的体内实验研究
The Effect of Integrin-linked Kinase on Rat Hepatic Fibrogenesis 整合素链接激酶在大鼠肝纤维化发展机制中的作用的研究
Study on the expression of genes in sinusoidal endothelial cells of rat liver with fibrogenesis 纤维化肝窦内皮细胞中基因表达的研究
CONCLUSIONS TNF-α, IL-6 and IL-10 play important roles in the progress of hepatic fibrosis, IL-1O has fibrogenesis-inhibiting effect on the CCI_4-induced rat hepatic fibrosis. 结论TNF-α,IL-6升高及IL-10降低在肝纤维化进程中起重要促进作用,予以外源性IL-10对CCl4诱导的肝纤维化有明显拮抗作用。
In situ study of myofibroblast during hepatic fibrogenesis in human being 人肝纤维化中肌纤维母细胞的组织原位研究
Increase of the expression of phosphorylated myosin light chain in rat liver tissue during hepatic fibrogenesis 大鼠肝纤维化过程中肝组织磷酸化肌球蛋白轻链表达增加
Conclusion PGE 1 significantly suppressed hepatic fibrogenesis in schistosomiasis japonica, whose mechanism was probably associated with suppressing of TGF-β 1 expression by PGE 1. 结论PGE1对日本血吸虫病肝纤维化的形成有抑制作用,其机理可能与PGE1抑制TGF-β1的表达有关。
The MMP-2/ TIMP-2 rate was higher in the early stage of liver fibrogenesis than in cirrhosis. 早期肝纤维化组MMP-2/TIMP-2比值高于肝硬化组;
Serum markers of hepatic fibrogenesis in cystic fibrosis liver disease 囊性纤维化肝病肝纤维化的血清标志物
This suggests TGF-β_1 play a key role in liver fibrogenesis and development. 认为TGF-β1在肝脏炎症、纤维化发展中起重要作用。
In recent years, there studies on PPAR γ and its ligand in hepatic fibrogenesis and the relation with hepatic fibrosis. 近年来,对PPARγ及其配体在肝纤维化中的作用及其与肝纤维化的关系进行了较多的研究。
CONCLUSION: The liver expresses leptin gene and protein, and Ob-RL. protein, their protein and phosphorylation level increases as the hepatic fibrosis develops, which contributes to the liver fibrogenesis induced by CCl4 with characteristic of steatohepatitis, besides the hepatic lipid peroxidation mechanisms. 结论:肝脏表达瘦素基因与蛋白和Ob-RL蛋白,瘦素蛋白及Ob-RL磷酸化水平随肝纤维化发展而增加,这是CCl4诱导的脂肪性肝纤维化除去脂质过氧化之外的另一重要发病机制。
The effects of Xiaochaihu Tang on markers of hepatic fibrogenesis in patients with chronic liver disease 改良小柴胡汤对慢性肝病患者肝纤维化标志物的作用
Inhibitory Effects of Rosiglitazone on Carbon Tetrachloride-induced Early Liver Fibrogenesis in Rats 罗格列酮对四氯化碳诱导大鼠早期肝纤维化的抑制作用
Conclusion Rho/ ROCK signaling pathways are changed in the process hepatic fibrogenesis. 结论Rho/Rho激酶信号转导通路在肝纤维化形成过程中发生变化。
Purpose To investigate the effects of collagen type ⅴ in liver fibrogenesis. 目的:探讨Ⅴ型胶原在肝纤维化中的作用。
Aims: It is obvious that the activation and proliferation of hepatic stellate cells ( HSC) is a key event in hepatic fibrogenesis. 目的:目前已明确肝星状细胞(Hepaticstellatecells,HSC)的激活和增殖在肝纤维化的形成中起决定性作用。
PURPOSE To study the roles of cytokines transforming growth factor ( TGF)-β 1, platelet-derived growth factor ( PDGF)-BB and basic fibroblast growth factor ( bFGF) in human hepatic fibrosis in order to make progress in investigation of liver fibrogenesis. 研究和探讨转化生长因子(TGF)-β1、血小板源性生长因子(PDGF)-BB、碱性成纤维细胞生长因子(bFGF)在人肝纤维化中的作用,进一步阐明人体慢性肝病纤维化发生机制。
Studies indicated that activated hepatic stellate cell ( HSC) is the primary ECM-producing cells in hepatic fibrogenesis; 研究表明活化的肝星状细胞(hepaticstellatecellHSC)是肝纤维化过程中ECM的主要合成细胞;
Objective To observe the expressive change of phosphorylated myosin light chain ( p-MLC) belonged to Rho signaling pathways in rat liver tissue during hepatic fibrogenesis. 目的观察Rho信号通路信号分子磷酸化肌球蛋白轻链(phosphorylatedmyosinlightchain,p-MLC)在实验性大鼠肝纤维化组织中的表达规律。
Effect of cyclooxygenase-2 on liver fibrogenesis induced by CCl_4 in rats 环氧合酶-2在CCl4诱导大鼠肝纤维化形成中的作用
Liver fibrogenesis caused by HSC activation which is an important pathologic stage during the development of HCC. HSC活化是肝纤维化发生的主要原因,肝纤维化是肝癌前病变的重要病理阶段。
Recent basic and clinical investigations demonstrate that liver fibrogenesis is accompanied by pathological angiogenesis and sinusoidal remodeling, which critically determine the pathogenesis and prognosis of liver fibrosis. 新近的基础与临床研究还证实,肝纤维化时发生病理性血管生成与肝窦重构,对肝纤维化的病理进程及治疗预后有重大影响。