Chronic EGFR kinase inhibition rapidly switched the HER network from dependence on EGFR to HER2. 持续的EGFR激酶抑制作用能够快速开启HER信号网络由EGFR向HER2转变。
Therefore, it would also provide necessary evidence to test EGFR mutations for the use of Gefitinib in CRCs. 因此,检测大肠癌EGFR外显子突变也为将吉非替尼疗应用于大肠癌提供理论依据。
Construction and expression of humanized anti-EGFR antibody 新型抗EGFR人源化抗体基因的构建和表达
Do regular pathology, VEGF, EGFR and immunohistochemical method CD34 expression and mark observation capillary is calculated. 做常规病理、VEGF、EGFR和CD34免疫组化方法标记观察毛细血管表达情况并进行计算。
Expression of EGFR 、 TGF-α、 Signal Transducers and Activators of Transcription 3 and Related Factors in Laryngeal Carcinoma TGF-α、EGFR及信号转导和转录激活因子3在喉癌组织中的表达及相关性研究
Erlotinib is a small molecule tyrosine kinase inhibitor that efficiently blocks EGFR. 厄洛替尼是一种小分子的酪氨酸激酶抑制剂,它能有效地阻断EGFR的作用。
Expression of SHP-1 and EGFR in or around mammary cancer tissue SHP-1和EGFR在乳腺癌及癌旁组织中的表达
The overexpression of the epidermal growth factor receptor and its ligands correlates with rapidly progressive disease and resistance to chemotherapy. 表皮生长因子受体(EGFR)及其配体的过表达与疾病的迅速进展和对化疗的耐药有密切的联系。
The results also demonstrate that EGFR signaling pathway is an important target in pancreatic cancer. 该研究也揭示了EGFR通路在胰腺癌的治疗中是一个重要的靶点。
In healthy cells, EGFR triggers growth in response to an activating signal that comes from outside the cell. 在健康细胞中,EGFR通过感应来自细胞外的激活信号激发细胞生长。
The next step was to pinpoint how one EGFR kinase domain would switch on another. 下一步是精确地研究一个EGFR激酶结构域是如何开启另外一个激酶的。
EGFR mRNA and Angiogenesis, Chemotherapy Resistance in Ovarian Carcinoma EGFRmRNA与卵巢癌血管生成及化疗耐药关系的研究
Influence of siRNA on the ovarian carcinoma cell cycle and EGFR expression siRNA对卵巢癌细胞周期及EGFR表达的影响
Conclusion: The expression of EGFR and VEGF is positively correlated with the carcinogenesis and metastasis of ovarian carcinoma, and there might be a synergistic effect between the2. 结论:EGFR和VEGF基因高表达与卵巢癌的发生及转移有相关性,两者可能有协同作用。
EGFR played an important role in the development of ovarian cancer. EGFR在卵巢癌的发生、发展过程中起着重要的作用。
Response rates to epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors in cancer treatment have been surprisingly and disappointingly low. EGFR酪氨酸激酶抑制剂在肿瘤的治疗中的反应率是出乎意料和令人失望的低。
Estimated glomerular filtration rate ( eGFR) and diastolic blood pressure showed no significant seasonal variations. 而患者的估计肾小球滤过率(eGFR)和舒张压则没有显示出明显的季节性变化。
Protein Expression of EGFR 、 Ras and Gene Mutations of K-ras in Colorectal Carcinoma 大肠癌中EGFR、Ras蛋白表达及K-ras基因突变的研究
Detection and Its Clinical Significance of EGFR Gene Mutation and Gene Amplification in 187 Patients with Non-small Cell Lung Cancer 187例非小细胞肺癌中EGFR基因突变和扩增的检测及其临床意义
Expression of EGFR, WT-1, CD10 and OTR in endometrial stromal sarcomas EGFR、WT-1、CD10和OTR在子宫内膜间质肉瘤中表达研究
Conclusions: Basal cytokeratin and EGFR expression are both highly prevalent among triple-negative breast cancers. 结论:三阴乳腺癌均高表达基底细胞角蛋白和EGFR。
Correlation between single nucleotide polymorphism of EGFR gene and colorectal carcinoma EGFR基因单核苷酸多态性与结直肠癌的相关性
Targeting EGFR pathway as a potential therapeutic strategy for pancreatic cancer has been developed. 以EGFR通路为靶点这样一个对胰腺癌具有潜力的疗法已经得到发展。
In their structural studies, those scientists had found only the active conformation of EGFR in their protein crystals. 在他们的结构研究中,这些科学家已经发现,在他们制备的蛋白质晶体中,只存在活性构象的EGFR。
The possible binding mode between EGFR and a4-anilinoqunazoline inhibitor was predicted by using molecular dynamics and MM/ PBSA. 采用分子动力学和MM/PBSA相结合的方法预测了表皮生长因子受体和4-苯胺喹啉类抑制剂的相互作用模式。
TGF-β Suppresses EGFR/ MAPK Signaling and Proliferation in Asthmatic Epithelial Cells TGF-β抑制哮喘上皮细胞中EGFR/MAPK信号通路和细胞增殖
But these drugs called EGFR inhibitors, such as cetuximab, have not been very effective against colon cancer. 但这些称为EGFR抑制因子如西妥昔单抗的药物对结肠癌的治疗还不是很有效。
The Study on Gene Amplification of EGFR in Bronchioloalveolar Carcinoma and Conventional Adenocarcinoma of the Lung 细支气管肺泡癌和肺腺癌EGFR基因扩增的研究
Expression and Significance of EGFR, p-EGFR and p-IGFR-1 β in Human Colorectal Cancer Cell Lines and Specimen Tissues 结肠癌细胞株和组织中EGFR、p-EGFR和p-IGFR-1β的表达及意义
Targeting both kinase-dependent and kinase-independent functions of EGFR may be necessary for more successful therapy in the future. 同时针对EGFR激酶依赖和激酶不依赖的功能可能是以后开展更成功的肿瘤治疗所必须的。