Conclusions The exhaustion and synthesis disturbance of ATP may explain the generation of diaphragm fatigue, and the reduction of dynamophore and ultrastructural injuries of the cells induced by oxygen free radicals may also contribute to this result. 结论隔肌细胞ATP过度消耗及合成障碍,直接供能物质减少以及氧自由基对亚细胞结构损伤可能是隔肌起搏后膈肌疲劳发生的原因。