Effects of MK-801 and Schizandrol A on DA/ DOPAC Measured by Voltammetry in Ischemic Rat Striatum 伏安法测定MK-801和五味子醇甲对DA/DOPAC的影响
When treated with desferal, the content of DA and its metabolites was much higher compared with the iron overloaded group ( P < 0.01). 去铁胺干预组Str内DA,DOPAC,HVA含量,比葡聚糖铁负载组明显升高,差别有高度统计学意义(P<0.01)。
The extracellular DA and DOPAC were collected by the push-pull method in the ventral and dorsal hippocampus and their contents were measured by high-performance liquid chromatography with electrochemical detection ( HPLC-EC). 同时采用推挽灌流技术收集海马细胞外液,应用高效液相色谱-电化学法检测多巴胺及双羟苯乙酸含量。
MAIN OUTCOME MEASURES: Improvement of rotation behavior and changes of dopamine and DOPAC were observed. 主要观察指标:PD大鼠旋转行为改善以及多巴胺和DOPAC含量变化。
In comparision, the level of DOPAC increased gradually when air-condition temperature was more than 28 ℃ and reduced gradually when air-condition temperature was less than 27 ℃. 与此相比较:1.当空调温度高于28℃时,DOPAC水平逐渐增加,当空调温度低于27℃时,DOPAC水平逐渐降低;
Results Compared with model group, the behaviors of rats in acupuncture group were significantly improved ( P < 0.01). The content of DA, HVA and DOPAC in striate body of rats with PD in acupuncture group were increased significantly ( P < 0.01). 结果与模型组比较,针刺后PD大鼠行为学明显改善(P<0.01),同时针刺组大鼠纹状体DA及代谢产物的含量均显著增加(P<0.01)。
The Effect of Acupuncture on the Content of Dopamine, HVA and DOPAC in Striate Body of Rats with Parkinson's Disease 针刺对帕金森模型大鼠纹状体多巴胺及代谢产物含量的影响
The content of corpus striatum dopamine, DOPAC and HVA were measured with high performance liquid chromatography. 利用高效液相色谱检测大鼠脑内多巴胺、二羟苯乙酸和高香草酸含量。
Catalpol ( 10 mg/ kg for 10 days) improved the cognition of mice, increased the content of dopamine and DOPAC in mice midbrain and striatum. 借助于高效液相考察梓醇对PD小鼠脑组织多巴胺(DA)及其代谢物(DOPAC)含量的影响,发现梓醇治疗10天能提高中脑、纹状体内多巴胺及其代谢物的含量。
Marked depletion of DA, DOPAC and HVA and significant elevation of DOPAC/ DA and HVA/ DA ratios were found in the caudate nucleus, putamen and substantia nigra of the monkeys with generalized parkinsonism and hemiparkinsonism ( lesioned side). 结果发现:(1)6只双侧和4只偏侧帕金森病猴模型的尾状核、壳核和黑质DA及其代谢产物显著降低,DOPAC/DA和HVA/DA比值明显增高;