Results There were constriction, emphraxis, dilation, congestion and sinusoidal capillarization in the hepatic sinusoidal and Disse's space lesion. 结果其病变有狭窄、阻塞、扩张、窦周隙淤血、肝窦毛细血管化表现。
The lumen of the bile canaliculus and the space of Disse were occluded by many microvilli extended by hepatocytes. 胆小管腔和窦周隙内浸润许多由肝细胞发出的微绒毛结构。
Liver sinusoidal and Disse's space lesion may play an important role in hepatic microcirculation disturbance of chronic hepatitis B 肝窦及窦周隙病变在慢性乙型肝炎肝微循环障碍中担当关键角色
The fenestra of hepatic sinusoid endothelial cells disappeared, basement membrane continued and ( thickened,) and Disse diastem collagen fiber increased. 肝窦内皮细胞窗孔消失,基膜连续并增厚,狄氏间隙胶原纤维增多。
In the patient of subacute severe HNANB ( E), the acidophile degeneration was seen chiefly in the hepatic cells and obvious bile stasis in Disse spaces and sinusoids. 亚急性重症型肝炎病人的肝细胞以嗜酸性变为主,Disse间隙及肝窦内淤胆明显。
Type ⅰ, ⅲ collagens were mainly expressed in walls of liver sinus and central veins, Disse cavity, and around granuloma of worm ova. 型胶原表达在肝窦壁、中央静脉壁、Disse腔、虫卵肉芽肿内及其周围,呈弥漫状分布,伴有门管区胶原纤维隔形成和窦壁完整的基膜形成;
[ Background and Objective] Hepatic fibrosis which is characterized by the activation and proliferation of hepatic stellate cell ( HSC), associated with the production and deposition of extracellular matrix ( ECM) in the Disse's space is a pathological response to various chronic liver diseases. [研究背景及目的]肝纤维化(hepaticfibrosis)是肝脏对慢性损伤的一种修复反应,以细胞外基质(Extracellularmatrix,ECM)在肝内过多沉积为特征。
HE and a reticular fiber staining were used, and the expression of TGF-β 1 in liver tissues was measured by an immunohistochemistry. The collagen deposit at Disse space was observed with a scanning electron microscope. 留取肝组织,行HE和网织纤维染色,采用免疫组织化学方法检测肝组织中转化生长因子β1的表达,电子显微镜下观察HSC的超微结构变化及狄氏腔内胶原纤维沉积情况。
Results: CTGF was not detected in normal controls. TGF β 1 was detected little in normal controls. Collagen I, III were distributed in portal tracts, endothelium in central vein and space of Disse. 结果:正常对照组CTGF不表达,TGFβ1微量表达,I、III型胶原主要分布在门静脉、中央静脉内皮下以及Disse间隙。
Localization of fibronectin was studied in rat cirrhosis induced by CCL_4 with electron immunohistochemical microscope. It was observed that fibronectin located in the space of Disse, the surface of endothelium and the surface of microvilli of hepatocytes. 应用免疫电镜对四氯化碳诱发大鼠肝硬化中纤维联接蛋白的演变进行了定位研究,发现在正常肝组织内纤维联接蛋白主要位于血窦内皮细胞表面、肝细胞血窦缘的微绒毛表面和Disse间隙内。
Disorders of hepatic sinusoids and Disse space in chronic viral hepatitis: it's relationship with hepatic microcirculation 慢性病毒性肝炎肝窦和Disse腔病变与肝微循环的关系
A large number of interstitial collagen and other ECM components deposite in the Disse space and eventually will lead to liver fibrosis. 大量间质胶原和其他ECM成分,首先沉积于Disse间隙,最终导致肝纤维化。