Objective: To study the plasma concentrations and pharmacokinetic parameters of 6,7 dimethoxycoumarin after oral administration of Herba Artemisiae Scopariae decoction and Yinchenhao decoction. 目的:测定大鼠灌胃给予茵陈蒿单煎液与茵陈蒿汤后,茵陈蒿中药效物质成分6,7二甲氧基香豆素的血药浓度,研究其药物动力学行为。
Effect and mechanism of 6, 7 dimethoxycoumarin on acute renal failure 6,7-二甲氧基香豆素抗急性肾功能衰竭的作用机制研究
Study on Main Metabolites of 6,7-dimethoxycoumarin in Rat's Body 6,7-二甲氧基香豆素在大鼠体内主要代谢产物的研究
CONCLUSION: The method is simple and accurate and can be used to determin the concentration of 6,7 dimethoxycoumarin in plasma samples and to study pharmacokinetics in rats. 结论:本法操作简便,可应用于大鼠血浆中6,7二甲氧基香豆素浓度的测定及其药动学研究。
AIM: To develop a reversed phase high performance liquid chromatography ultraviolet method to determine 6,7 dimethoxycoumarin in rat plasma and to study the pharmacokinetic process of 6,7 dimethoxycoumarin in rats. 目的:建立大鼠血浆中6,7二甲氧基香豆素反相高效液相色谱紫外检测方法,并研究其在大鼠体内的药动学过程。