The intramolecular cyclization occurred with the catalysis of palladium dichloride after α-alkylation of acetylacetone O-methyloxime with 1,4-dibromo-2-butene, and corresponding dihydropyrrole was obtained in two steps. 乙酰丙酮O-甲基肟与1,4-二溴-2-丁烯进行α位烷基化反应后在氯化钯的催化下进行分子内环合反应,两步生成了二氢吡咯衍生物。
The design, synthesis and activity of tetrahydropyrimidine and dihydropyrrole derivatives as COX-2 inhibitors are then presented in detail. 然后详细介绍了四氢嘧啶和二氢吡咯衍生物作为COX-2抑制剂的设计、MCR合成及其生物活性研究。