Effect of desipramine on sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia 地昔帕明对心肌缺血后交感神经重构和室颤阈值的影响
Desipramine overdose is more likely to result in death than overdose with other tricyclic antidepressants, notes a company letter sent to healthcare professionals. 在该公司发给医护人员的一份信中提到,与其他三环类抗抑郁药过量相比,地昔帕明过量更易导致死亡。
Desipramine Pretreatment Improves Sympathetic Remodeling after Myocardial Ischemia 地昔帕明预处理改善心肌缺血后的交感神经重构
AIM To study the effect of desipramine ( DMI) on proliferation inhibition and apoptosis induction of rat glioma C6 cells. 目的研究地昔帕明(DMI)对大鼠脑胶质瘤C6的增殖抑制和凋亡诱导作用,为三环类抗抑郁药作为肿瘤辅助治疗提供新的理论和实验依据。
Purpose: To study the antiproliferative effect of tricyclic antidepressant desipramine ( DMI) alone or in combination with chemotherapeutic agent teniposide ( VM 26) against rat C6 glioma cells. 目的:研究三环类抗抑郁药地昔帕明(DMI)对脑胶质瘤C6细胞增殖的调控作用,并探讨与临床常用治疗脑瘤的化疗药物替尼泊苷(VM26)合用的协同效应。
Desipramine inhibited proliferation of glioma C6 cell via ceramide pathway 地昔帕明对胶质瘤C6细胞增殖抑制的神经酰胺通路
The concentration-time curve of desipramine, the major metabolite of imipramine, fitted in with a one-compartment kinetic model. 主要代谢产物去甲丙咪嗪药时曲线符合一室线性动力学。
Effect of desipramine alone and in combination with teniposide on proliferation in rat C6 glioma cells 地昔帕明单用和合用替尼泊苷对大鼠脑胶质瘤C6细胞增殖的调控作用
IHS ( 20 mg · kg-1 po) also elicited significant decrease in immobility time in forced swimming test in rats, which was comparable to the effect of desipramine ( 40 mg · kg-1, po). 同样,poIHS20mg·kg-1也缩短大鼠强迫性游泳的不动时间,其效果与加地昔帕明40mg·kg-1相当。
Effect of desipramine on proliferation inhibition and apoptosis induction in rat glioma C6 cells 地昔帕明对脑胶质瘤C6细胞的增殖抑制和凋亡诱导作用
Screening studies on the antidepressant desipramine related genes using microarray gene chip 微矩阵基因芯片筛选抗抑郁剂地昔帕明相关基因的研究