Plasmid-encoded 16S rRNA methylase, which confer high-level resistance to 4, 6-disubstituted deoxystreptamine aminoglycosides ( such as amikacin and gentamicin) in many Gram-negative pathogens, is a novel discovered resistant determinant. 质粒介导的16SRRNA甲基化酶是近年来新发现的一种耐药决定因子,可导致革兰氏阴性细菌对4,6-二取代基-脱氧链霉胺类氨基糖苷类药物(如庆大霉素、阿米卡星等)高水平耐药。
Sisomicin, an important aminoglycosides in clinic, belongs to 4,6-disubstituted deoxystreptamine antibiotics, and is produced by Micromonospora inyoensis. 西索米星,临床上重要的的氨基糖苷类抗生素,属4,6双取代2脱氧链霉胺类抗生素,由依尼奥小单孢菌产生。