6-Methylpurine-2 '-Deoxyriboside ( MePdR), an anticancer prodrug, was synthesized using MeP and dU by recombinant purine nucleoside phosphorylase of Escherichia coli. 6-甲基嘌呤-2′-脱氧核苷(MePdR)是一种新型抗癌药物,它作为药物前体应用于PNP自杀基因治疗系统可以选择性杀伤肿瘤细胞。
Enzymatic synthesis of 6-methylpurine-2 '-deoxyriboside by recombinant purine nucleoside phosphorylase Tritium labeled thymine deoxyriboside ( [ 3H] TdR) uptake was measured to observe DNA synthesis. 基因工程菌酶法合成抗癌新药6-甲基嘌呤-2′-脱氧核苷氚胸腺嘧啶核苷([3H]TdR)掺入法检测TP40对T24细胞蛋白质合成的抑制作用。