Accordingly, the demethylation drugs were developed and they have been used in clinical treatment and research, which confirmed that the drug is a kind of safe and effective anti-tumor drug. 据此,人们开发出了去甲基化药物,并已应用于临床治疗及研究,结果证实去甲基化药物是一类安全、有效的抗肿瘤新药。
One way these instructions are erased is through demethylation, the removal of specific chemical tags or methyl groups that dot the underlying DNA of cells. 这些化学标签去除的一个方式就是去甲基化,即移除细胞DNA上分布的特异性化学标签或者甲基。
Effect of As_2O_3 on demethylation of SHP-1 gene in human lymphoma cell line T2 三氧化二砷对淋巴瘤T2细胞株SHP-1基因的去甲基化作用
The demethylation rate was related to the pathological and disease stages differentiation. 该区的去甲基化发生率与胃癌组织的病理分级以及与临床分期有关。
The Effect of Demethylation by Hydralazine on Estrogen Receptor α Negative Human Breast Cancer Cell Line MDA-MB-231 肼苯哒嗪对人乳腺癌细胞株MDA-MB-231雌激素受体α去甲基化的影响
CHH methylation of small transposable elements is increased in embryos, suggesting that endosperm demethylation enhances transposon silencing. 胚中小的转座元件CHH甲基化作用发生了增强,表明了胚乳的去甲基化增强了转座元件的沉默。
In this article, the methylation and tumor, methylation and hematologic diseases, methylation detection methods, demethylation therapy in leukemia and so on are reviewed. 本文对甲基化与肿瘤、甲基化与血液病,甲基化的检测方法和去甲基化治疗等问题进行了综述。
Advances of Research on Demethylation Therapy for Hematologic Malignancies& Review 恶性血液病去甲基化治疗的研究进展
Scientists have already found out how the methyl groups are attached. The reverse process of demethylation, however, has been poorly understood so far. 科学家们已经发现甲基团是如何被黏附的了,但是对逆转的去甲基化过程却知之甚少。
Effects of DNA Demethylation and Histone Deacetylase Inhibition to Estrogen Receptor of Prostate Cancer Cell-Lines 去甲基化抑制剂和组蛋白去乙酰化转移酶抑制剂对前列腺癌细胞株雌激素受体的影响
Histone Lysine Demethylation and Gene Regulation 组蛋白赖氨酸去甲基化与基因调控
Transcription and Expression Study of Promoter Region Demethylation on CKIs Genes in Human Colorectal Cancer Cell 启动子区去甲基化对肠癌RKO细胞CKIs基因转录表达的研究
The Effect of Demethylation of Genomic DNA on Cell Aging Process DNA去甲基化对细胞衰老的影响
Effect of DNA demethylation on gene expression from Marek's disease virus DNA去甲基化对马立克氏病病毒(MDV)基因表达的影响
The demethylation reaction was found when ZnCl_2 instead of ZnSO_4 was used in the course of direct amination. 在使用硫酸锌代替氯化锌进行直接胺化反应的过程中,发现并没有直接胺化的产物而是发生了脱甲基反应,有关这一反应的机理和应用有待进一步研究。
Objective: The effect of DNA demethylation on aging process and telomere length was studied. 目的:研究DNA甲基化水平变化对细胞衰老进程和端区长度的影响。
Objective To investigate the mechanisms of arsenic trioxide ( As 2O 3) induced demethylation. 目的探讨三氧化二砷(As2O3)去甲基化作用的机制。
Procaryotic M enzymes as model molecule play an important role in studying mechanism of methylation and demethylation. 原核M酶作为模式分子,在研究和解释甲基化作用和去甲基化作用机制中起到了重要作用。
Development of Histone Methylation and Demethylation 组蛋白甲基化和去甲基化研究进展
Experiment studied the demethylation reaction of formononetin transforming into daidzein. 研究了以芒柄花黄素为原料转化成黄豆苷元。
Aberrant methylation, the methylation of tumor suppressor genes and the demethylation of oncogenes, is believed to be the main mechanism for activating the oncogene and inactivating the tumor suppressor gene. 基因的异常甲基化,即抑癌基因的甲基化与癌基因的去甲基化被认为是抑癌基因失活和癌基因激活的主要机制。
Achieve DNA active demethylation. 实现DNA主动去甲基化。
The reaction of hydroxylation, demethylation, dehydration or dehydroxylation occurred in the incubate system. 在该温孵体系中,黄皮酰胺多发生羟基化反应、脱甲基化反应、脱水反应、脱羟基化反应等。
Metabolic reactions involved are oxidation, reduction, demethylation, sulfate conjugation and glucuronic acid conjugation. 涉及的代谢反应有:氧化、还原、去甲基化、与硫酸结合、与葡萄糖醛酸结合。
Research for aberrant DNA methylation of tumor suppressor genes, DNA-methyltransferases and demethylation treatment are also hotspots. 近年来,抑癌基因的高甲基化以及DNA甲基转移酶和去甲基化酶的研究,成为研究的热点。
LHR showed demethylation in mouse model of PCOS, but others had similar methylation level in both groups. 结果显示,LHR在DHEA诱导的小鼠PCOS模型中发生了明显的去甲基化;但是,其他检测基因维持与对照组相似的甲基化水平。
TSA might have synergistic effect on demethylation of EGCG through changing the chromatin configuration. TSA可能通过改变染色质结构,增强EGCG的去甲基化作用。