AIM To study relationship between the firing pattern and sensitivity of substantia nigra compacta neurons to norepinephrine, to certify universality of "non period sensitivity" in nervous system. 目的研究黑质致密部(SNc)神经元的放电型式与其对去甲肾上腺素(NE)敏感性的关系,探讨非周期敏感现象的普遍性。
Methods SD rats were injected respectively with 8 mg Lactacystin ( Lactacystin group), sodium saline ( NS group) and 12 mg 6-OHDA ( 6-OHDA group) by stereotaxic unilateral injection into the pars compacta of substantia nigral. 方法分别在大鼠一侧黑质致密部注射蛋白酶体抑制剂Lactacystin8mg(Lactacystin组)、等体积生理盐水(NS组)和6-羟基多巴胺(6-OHDA组)12mg;
The X-ray observation of the thickness of substantia compacta of tibia and its biomechanic explanation 人体胫骨密质厚度变化的X线观察及其生物力学机制的探讨
[ Method] Through posterior transpedicular and vertebrae, wedged osteotomy was continually performed until anterior substantia compacta of vertebrae. [方法]该器械通过后方入路(常规器械切除脊椎后结构)经双侧椎弓根、椎体行楔形截骨,直到椎体前缘皮质下。
A behavioral evaluation of substantia nigra pars compacta lesioned rats 大鼠黑质毁损程度的行为学评价
Results: TH positive neurons and neurites in the right substantia nigra compacta ( SNc) and striatum of the rat model of PD were decreased ( P < 0.01), which proved successful PD models. 结果:模型组大鼠右侧黑质致密部TH阳性神经元及纹状体TH阳性纤维明显减少(P<0.01),证明模型制作成功。
Relationship between sensitivity to norepinephrine and firing pattern of substantia nigra compacta neurons 黑质致密部神经元对去甲肾上腺素的敏感性与其放电型式的关系
Significant low signal intensity on T2 WI localized in bilateral globus pallidus and pars compacta of the substantia nigra in two patients, and the "eye of the tiger" sign in one patient. T2WI均表现为苍白球、黑质等部位对称性低信号,其中1例为虎眼征。
The application of measurement of the width of pars compacta of substantia nigra in differential diagnosis on Parkinson's disease and vascular parkinsonism on MRI 磁共振测量黑质致密带宽度在帕金森病和血管性帕金森综合征鉴别诊断上的应用
Objective To evaluate the value of measurement of the width of pars compacta of substantia nigra ( SNc) and SNc's ratio to midbrain diameter in diagnosing Parkinson's disease ( PD) and differentiating PD from vascular parkinsonism ( VP) on routine MRI. 目的探讨在常规磁共振(MRI)上测量黑质致密带(SNc)宽度及其与中脑直径的比值对帕金森病(PD)和血管性帕金森综合征(VP)的诊断和鉴别诊断价值。
MAO B is believed to convert MPTP into 1 methyl 4 phenylpyridine ( MPP+) which is cytotoxic product responsible for the pars compacta of substantia nigra ( SNc) neuronal destruction. 单胺氧化酶B被认为可使MPTP转化为甲苯吡啶(MPP+),而MPP+是损毁黑质致密部神经元的细胞毒性物质。
Parkinson's disease ( PD) is a neurodegenerative disorder in the central nerve system which characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta ( SNpc). 帕金森病(Parkinson'sdiseasePD)是一种以锥体外系黑质多巴胺能神经元进行性损害为主要病理表现的中枢神经系统退变性疾病。
Evaluating value of the ratio of the width of pars compacta of substantia nigra to midbrain diameter in Parkinson's disease 黑质致密带宽度和中脑直径比值对帕金森病的评估价值
The pathology of PD can be attributed to the selective loss of dopaminergic ( DAergic) neurons in the substantia nigra pars compacta ( SNPc). PD在病理学上以黑质致密部多巴胺能神经元选择性变性缺失为特点。
Pathologically, PD is characterized by the presence of Lewy bodies and selective loss of dopaminergic neuron in the substantia nigra pars compacta ( SNc). 帕金森病在病理学上的主要特征是路易小体形成和黑质多巴胺能神经元选择性丢失。
The characteristic pathogenesis of PD is degeneration of dopaminergic neurons in nigra zona compacta and decrease of the neuron-transmitter dopamine content in striatum, which lead to dysfunction of the dopaminergic neurons and relative domination of cholinergic function. All the above alterations finally result in development of dyskinesis. PD的病理特征是患者黑质致密体部位的多巴胺神经元变性,纹状体内多巴胺能神经中递质含量显著减少,导致黑质纹状体多巴胺神经功能低下而胆碱能神经功能相对占优势,从而产生运动障碍。
The pathophysiological basis of PD is a severe deficiency of dopamine ( DA) in the striatum, resulting from a selective and progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta ( SNpc). 主要病理基础是中脑黑质致密部(SNpc)多巴胺能神经元选择性进行性退变,继而引起纹状体多巴胺(DA)严重缺乏。
This system includes the dopamine neurons locating in ventral tegmental area ( VTA) and substantia nigra compacta ( SNc) and their projection areas dorsal striatum ( caudate and putamen), nucleus accumbens ( NAc), hippocampus, prefrontal cortex ( PFC) and amygdala. 该系统包括位于腹侧被盖区和黑质致密层的多巴胺神经细胞,以及该类细胞的主要投射区:背部纹状体、伏核、海马、前额皮质和杏仁核[2,3]。
It was characterized by a selective and progressive loss of dopaminergic ( DA) neurons in substantia nigra pars compacta ( SNpc). 其主要特征是中脑黑质多巴胺能神经元的选择性的丢失。
The pathological changes are characterized by deficiency of dopaminergic neurons in substantia nigra compacta and formation of Lewy body ( LB) in neurons. 病理改变以黑质致密层多巴胺神经元部分缺失、神经元中有路易小体(LewyBody,LB)形成等为特点。
The major pathologic hallmark of PD is that the death of most of dopamine neurons in the pars compacta of substantia nigra, with the obvious dopamine deletion in the striatum. 其主要病理特征是黑质致密部多巴胺能神经元大量死亡,纹状体内多巴胺含量显著减少。