The Synthesis of Novel Cinchona Alkaloids-derived Phosphite Ligands and Their Application in Asymmetric Catalytic Reaction 金鸡纳生物碱衍生的亚磷酸酯配体的合成及其催化性能研究
Cinchona: any of several trees and shrubs of the genus cinchona, native chiefly to the Andes and cultivated for bark that yields the medicinal alkaloids quinine and quinidine, which are used to treat malaria. 金鸡纳树:一种金鸡纳属的树木和灌木,原产于安第斯山区,其树皮含有治疗疟疾的药用生物碱奎宁和奎尼定,因而被栽植。
Preparation of Molecularly Imprinted Monolithic Capillary Column for Separation of Diastereomers of Cinchona Alkaloids by Pressure-Assisted Capillary Electrochromatography 原位分子印迹毛细管电色谱柱的制备及其对非对映异构体的分离
Aldol Reactions of α-Keto Acid Esters and Acetone Catalyzed by Cinchona Alkaloid Derived Primary Amines 金鸡纳碱衍生二胺催化丙酮和α-酮酸酯的Aldol反应
The inclusion complexation behavior of sulfoantocalixarenes with four cinchona alkaloids was investigated by means of fluorescent spectra. 采用荧光光谱方法研究了三种磺化杯芳烃与四种金鸡钠碱药物分子的键合行为。
Studies on Asymmetric Catalysis and Biological Activity of Cinchona Alkaloids 金鸡纳生物碱衍生物催化不对称反应及生物活性的研究
Gin gets its flavor from juniper tree berries, and the quinine in tonic comes from the cinchona tree. 杜松子酒的口味来源于杜松子的浆果,而碳酸奎宁水中的奎宁来自金鸡纳树。
A New Sensitive Chemiluminescence System for Determination of Cinchona Alkaloids with FIA 测定金鸡纳碱的流动注射化学发光新体系
This paper focuses on the synthesis of cinchona alkaloid catalysts which contains rigid polybenzene moieties and their application in asymmetric catalytic reactions. 本课题所研究的是含有多聚苯刚性分子片段的金鸡纳碱类手性催化剂。
Research on Synthesis and Catalyzed Activity for Michael Reaction of α,β-unsaturated Ketone to a Cinchona Alkaloid Quaternary Ammonium Salt 一种手性金鸡纳季铵盐的合成及催化α,β-不饱和酮的Michael加成反应研究
For example, quinine, an effective antimalarial drug, comes from the bark of the cinchona tree and has long been used in traditional Latin American remedies. 例如,一种有效的抗疟疾药物奎宁来自于金鸡纳树的皮,而且长久以来被拉丁美洲的传统药物使用。
The reaction mechanism in tartrate modified catalysts and cinchona modified catalysts are also discussed. 对酒石酸及金鸡纳碱修饰型金属催化剂的反应机理也进行了探讨。
Applications of Cinchona Alkaloids in Chiral Separation 金鸡纳生物碱在手性分离中的应用
Catalytic Asymmetric Reduction of Acetophenone in the Presence of Some Metal Complexes of Cinchona Alkaloids 金鸡纳生物碱的金属络合物用于苯乙酮的不对称催化还原
Advances in the Asymmetric Synthesis of α-Amino Acids Catalysed by Polymer-supported Chiral Cinchona Phase Transfer Catalysts 聚合物负载金鸡纳碱类手性相转移催化剂制备手性α-氨基酸研究进展
Conclusion In the synthetic procedure to chiral docetaxel C_ ( 13) side chain, the expensive cinchona alkaloid derivatives can be recycled, which dramatically decreased the reaction cost. 结论在多烯紫杉醇手性C13侧链的合成过程中,对价格昂贵的金鸡纳生物碱衍生物配体进行了回收和再利用,大大降低了反应成本。
Four chiral P, N-ligands were synthesized in high yields from natural cinchona alkaloids under mild conditions. 以天然金鸡纳生物碱为原料,在温和条件下合成了4个手性膦氮配体。
Optically Active Polymers with Cinchona Alkaloids 2. Cinchonine-containing amphiphilic monomers and polymers 含金鸡钠碱的光活性聚合物2.含辛可宁的两亲单体及其两亲聚合物
The proper in-situ polymerization systems of acidic and basic compounds using amino acid derivatives and cinchona alkaloids as template molecules respectively were adopted for preparation of molecularly imprinted monolithic columns by systematically investigating the effect of polymerization conditions on pore structure and selectivity of resulting polymers. 本文分别以氨基酸衍生物和辛可纳生物碱为模板分子,系统研究了制备条件对聚合物孔结构和选择性的影响,建立了合适的酸性化合物和碱性化合物的原位印迹体系。
Quinine and other related cinchona alkaloids were chosen for the separation of some tart enantiomers of phenylalanine, aromatic acids and other acids. 奎宁和其它金鸡纳生物碱类化合物作为手性选择子可分离苯丙氨酸、芳香酸和其它手性酸。
Several novel mono-modified β-Cyclodextrin and γ-Cyclodextrin were prepared and their binding abilities with two cinchona alkaloids were investigated. 本文合成了几种简单修饰的β-和γ-环糊精,并考察了它们对金鸡纳碱的手性识别能力。
The MS behaviors and dissociation laws of four alkaloids in Cinchona were studied by direct infusion into electrospray ion trap mass spectrometry ( ESI-ITMS). 利用电喷雾离子阱质谱(ES-ITMS)技术进行了金鸡纳中4种喹啉类生物碱(奎宁、奎尼定、辛可宁和辛可尼定)的电喷雾质谱研究。
Synthesis of Chiral Diamine Ligands Derived from Cinchona Alkaloids and Their Catalytic Performance for Asymmetric Transfer Hydrogenation 金鸡纳生物碱衍生手性双胺配体的合成及其在不对称氢转移反应中的催化作用
These cinchona alkaloids derivatives were then applied to catalyze the asymmetric Henry reation of p-methoxybenzaldehyde with nitromethane. 以上述四种金鸡纳生物碱衍生物为催化剂,催化对甲氧基苯甲醛与硝基甲烷的不对称Henry反应。
The thermodynamic parameters in the separation of enantiomers of amino acid derivatives and diastereomers of cinchona alkaloids were calculated and the dissociation constants of cinchonine and cinchonidine on the cinchonine imprinted monolithic disk were determined by frontal analysis. 计算了氨基酸衍生物对映体以及辛可纳非对映异构体分离过程的热力学参数并利用前沿色谱法测定了辛可宁和辛可尼丁在盘状分子印迹整体柱上的离解平衡常数。
In consideration of the electronic effects and the influence of steric hindrance, by introducing benzyl into 9-OH of cinchona derivatives, four new kind of chiral phase-transfer catalysts has been synthesised and identified by 1H-NMR, IR, melting point and specific rotation. 3. 在考虑电子效应的同时考虑空间位阻的影响通过在金鸡纳衍生物9-OH上引入苄基,合成了四种新型的手性相转移催化剂。产物经1HNMR、IR、熔点、比旋光表征。
Owing to cinchona alkaloids the unique three-dimensional structure, associated with metals, they are widely used in asymmetric organic catalytic reactions. 金鸡纳生物碱因具有独特的立体结构,在不对称金属催化剂有机催化反应中应用广泛。