The preparation, mechanism of action, pharmacodynamics and pharmacokinetics properties of cidofovir are reviewed in this paper. 现对西多福韦的制备方法、作用机制、药效学及药动学性质等作一综述。
Cidofovir in Inhibiting Siha Cell Proliferation of Cervical Cancers 西多福韦抑制宫颈癌Siha细胞增殖作用的研究
Methods Cidofovir was synthesized via6-step reactions with cytosine as the starting material. 方法以胞嘧啶为起始原料,经六步反应合成西多福韦。
Progress in clinical trial of cidofovir 西多福韦临床研究进展
Among them, cidofovir is strongly resistant to various poxviruses. 其中,西多福韦对多种痘病毒具有很强的对抗作用。
Cidofovir can inhibit the growth of human cervical carcinoma Hela cell and Siha cell lines infected by human papillomavirus and induce cell apoptosis. 西多福韦对HPV感染的宫颈癌Hela细胞和Siha细胞及其荷瘤裸鼠肿瘤的增殖生长具有明显的抑制作用,并能诱导细胞凋亡。