Chemoprevention trials in otherwise healthy people require effective agents that are extremely safe& so safe that they can be taken for long periods with negligible risk. 另外,化学预防试验在健康人群中需要绝对安全的有效制剂&要安全到可被长期服用而危险性却微不足道。
These results establish an unambiguous role for BAX in apoptotic processes in human epithelial cancers and may have implications for cancer chemoprevention strategies. 这些结果证明BAX在人的皮肤癌的凋亡过程中明显作用和暗示它在癌的化学预防策略中的作用。
Be as thoughtful about the need for multiagent chemoprevention, not forgetting that diet is one version of this, as about the use of multiagent chemotherapy. 我们要多加考虑多制剂的化学预防的必要性。关于多试剂化疗方法的应用上,不要忘了饮食也属于这种方法。
New dosage forms of Chinese medicinal herb are irreplaceable and show great prospect in cancer chemoprevention. 药物研发方面具有不可替代的位置,开发前景巨大。
Conclusion: Ttelomerase could act as a surrogate endpoint biomarker for oral chemoprevention during OLK carcinogenesis. 结论:端粒酶可以作为口腔白斑癌变化学预防的替代性终点标记物监测口腔白斑癌变。
CONCLUSION: Chemoprevention with NSAIDs can be considered in patients following initial prophylactic surgery as an adjunct to endoscopic surveillance, to reduce the rectal polyp burden. 结论:在接受预防性手术的患者中,可以在内镜复查的基础上预防性应用非甾体类抗炎药以减少直肠息肉数目。
A better understanding of the significance of these markers will help us identify individuals most likely to benefit from chemoprevention using aspirin or NSAIDs. 了解这些指标的意义将有助于我们筛选出那些最有可能从服用阿司匹林或非甾体类抗炎药等化学预防中受益的人群。
The female hormone of soybean isoflavones is affecting on hormone secretion, metabolic biology activity, protein synthesis, growth factors activity, is the natural cancer chemoprevention agent. 大豆异黄酮的雌性激素作用影响到激素分泌、代谢生物学活性、蛋白质合成、生长因子活性、是天然的癌症化学预防剂。
Chemoprevention of Barrett's esophagus by celecoxib in rats 塞来昔布对实验性Barrett食管的作用研究
Cancer control efforts might also need to include chemoprevention, though currently available agents are controversial. 虽然现有化学制剂颇受争议,但癌症控制可能还是需要化学预防。
Effects of rosiglitazone, a PPAR γ ligand, on chemoprevention of MNNG-induced gastric cancer in rats PPARγ配体罗格列酮预防MNNG诱导的大鼠胃癌发生的实验研究
We need more sensitive, user-friendly, and less time-intense techniques to identify those at greatest risk of gastric adenocarcinoma for early endoscopic intervention or chemoprevention. 我们需要更敏感、更易操作和更省时间的技术来鉴别具有高危胃腺癌风险人群,以便早期内镜干预或化学药物预防。
Selective COX-2 inhibitors may be more useful in the chemoprevention and therapy of ER negative breast cancer, and COX-2 would be a new molecular target for breast cancer treatment in the future. NIM对MDA-MB-231细胞的抑制更为有效,提示COX-2选择性抑制剂对ER(-)的乳腺癌有更好的预防作用,COX-2的分子靶向治疗将成为乳腺癌预防和治疗的新途径。
Chemoprevention of gastric cancer by specific cyclooxygenase-2 inhibitor in rats 特异性环氧合酶-2抑制剂预防胃癌的实验研究
Role of Nrf2/ ARE in chemoprevention of cancer Nrf2/ARE在化学防癌机制中的作用
Conclusion: The anti-oxidative activity of spirulina platensis might plays an important role in cancer chemoprevention. 结论:螺旋藻的抗氧化作用可能是其发挥癌症化学预防作用的主要机制之一。
Conclusions Celecoxib maybe inhibit the growth of bladder cancer via inducing apoptosis of tumor cells and perhaps will become a choice of chemoprevention and adjuvant therapy of bladder cancer. 结论塞来昔布可能通过促进肿瘤细胞凋亡等途径对膀胱肿瘤产生抑制作用,可能成为膀胱肿瘤化学预防及治疗的辅助手段。
Chemoprevention of tamoxifen on benign breast disease in women 三苯氧胺对乳腺良性疾病的化学预防作用
These results might be valuable both in chemoprevention and in clinical treatment of leukemia. The two groups were followed up three years, and observed the incidence state of tuberculosis and the chemoprophylaxis of INH. 这为白血病的化学预防和临床辅助治疗提供一定的理论依据。预防组和对照纽人群均随访三年,观察结核病的患病情况和INH的化学预防效果。
The advances of ursolic acid in the aspect of chemoprevention and treatment in recent decade are reviewed. 综述了近十年来熊果酸在癌的化学预防和治疗领域的新进展。
Conclusion: COX-2 may be a new target for the therapy of cancer. COX-2 inhibitors have a good prospect in HCC chemoprevention and treatment though their effectiveness and safety need to be intensively studied. 结论:COX-2可能成为肿瘤治疗中的一个新靶点,COX-2抑制剂在肝癌的防治中有较好的应用前景,但其有效性和安全性还需进一步研究。
It was summarized the recent progresses of nonsteroidal antiinflammatory drugs ( NSAIDs) in the treatment and chemoprevention of cancers in the thesis, and the potential mechanisms as well. 本文简述了非甾体抗炎药(NSAIDs)在肿瘤化学治疗和预防方面应用的新进展,并对其作用机制进行了概述。
Hence, significant advances have been made, both by in vitro and in vivo studies showing that genistein is a promising agent for cancer chemoprevention and/ or treatment. 大量体外和体内研究结果均显示:染料木黄酮极有希望成为一种有效的癌化学预防和(或)癌症治疗药物。
Conclusion: The expression of COX-2 in sensitive cell strains is much higher than that in drug-resistant strains of ovarian cancer cell lines, providing basis for the chemoprevention of ovarian cancer. 结论:卵巢癌细胞系敏感株中COX-2表达明显高于耐药株,为卵巢癌的化学治疗提供了理论基础。
Cox-2 inhibitor may be a promising target for tumor chemoprevention and treatment. Cox-2选择性抑制剂有望成为NPC防治的新靶点。
Epidemiology and chemoprevention of esophageal squamous cell carcinoma 食管鳞状上皮细胞癌的流行病学和化学预防
AIM To study the anti oxidation and cancer chemoprevention mechanism of procyanidins extracted from Vitis vinifera. 目的探讨葡萄原花青素抗氧化和肿瘤化学预防作用机制。
One of the research objectives for chemoprevention is to discover effective drugs with low toxicity. 肿瘤预防研究的目的之一就是寻找高效、低毒的药物。
Tumor microenvironment suggest DJ-1 protein can serve as a target for cancer chemoprevention, Chemoprevention against cancer-causing factors in the early control, micro-environment through a variety of cells and cytokines affect tumor phenotype intervention. 提示肿瘤微环境中的DJ-1蛋白可以作为化学预防治疗癌症的靶点,化学预防可以在早期对致癌因素进行控制,通过对微环境中多种细胞及细胞因子的干预而影响肿瘤表型。
Key steps or rate-limiting enzyme can act as the target of chemoprevention in tumorigenesis. 肿瘤发生发展过程中的关键步骤或限速酶都可作为肿瘤化学预防的作用靶点。