ConclusionUnder the introduction of the outer magnetic field, the modified magnetic nanoparticles loaded CDDP could be collected within the targeting tumor and efficiently exert its antitumor effect. 结论载顺铂磁性纳米药物在体外磁场的引导下能聚集于肿瘤组织,发挥良好的抗肿瘤生物学效应。
The Effects of Sodium Tanshinone ⅱ A Sulphonate Combined with CDDP on Gastric Cancer Cells by Intraperitoneal Chemotherapy 丹参酮ⅡA磺酸钠联合顺铂腹腔化疗对胃癌生长的影响
Preparation of CDDP incorporated stealth niosomes and their properties after conjugation with BSA 顺铂隐形泡囊的研制及表面连接蛋白质前后的性质比较
Introduction: Cisplatin ( Cis-diamminedichloroplatinum, CDDP) is an anticancer medicine that has been widely used currently. 前言顺铂(Cis-diamminedichloroplatinum,CDDP)是当前临床上应用较广泛的一种肿瘤化疗药物。
Methods The cytotoxicity of TNP-470 、 CDDP on human tongue cancer cells ( Tca8113) was detected with MTT assay in vitro. 方法MTT法测定TNP-470、顺铂(CDDP)对体外培养人舌癌Tca8113细胞增殖的抑制作用。
Among many chemotherapeutic regimens in our country, CDDP is also considered the primary agent. 在我国的多种癌症治疗中,CDDP也作为首选药物。
These phenomena were not observed in SRCS treated by CDDP and TAM. 而CDDP和TAM无上述现象。
Conclusion CDDP, VCR and BLM can effectively inhibit Hela cell's growth, but their combination use may make antagonist action. 结论CDDP、VCR、BLM能有效抑制Hela细胞生长,联合应用出现拮抗作用。
Conclusions: 1 The multidrug resistant gene GST π is associated with CDDP 、 ADM and CTX. 结论:1.多药耐药基因GSTπ与治疗卵巢癌的一线抗癌药物CDDP、ADM和CTX的化疗耐药有关。
Conclusion: A human esophageal carcinoma drug-resistant cell line Ec9706/ cDDP is established successfully and the mechanism of drug resistance is related to expression of pol β, DHFR, GST and TPO. 结论:成功建立了人食管癌顺铂耐药细胞系Ec9706/cDDP,其耐药性的产生与polβ、GST、DHFR、TPO等基因的异常表达有关,而与mdr1、MRP表达的关系不密切。
Experimental Study of Ultrasound Hyperthermia Combined with CDDP on Human Oral Squamous Cell Carcinoma Xenografts in Nude Mice 超声热疗联合顺铂治疗口腔鳞癌裸鼠移植瘤的实验研究
Conclusion: The expressions of Bcl 2 and Bax protein have changes under CDDP administration, Bcl 2 family proteins should play an important role in regulation of cochlear cells apoptosis. 结论:CDDP作用下,Bcl-2和Bax表达发生变化,Bcl-2蛋白家族参与了CDDP诱导的耳蜗细胞凋亡。
It has been reported that oxidative stress was one of the mechanisms of CDDP-induced cytotoxicity. CDDP肾毒性的机制之一是氧化应激,但是氧化性损伤并不能完全解释顺铂诱导的肾毒性。
In non-CDDP group, the change of nitric oxide content in serum is not obvious before and after chemotherapy. 非CDDP组化疗前后血清NO含量变化不明显。
Except for ADM, L3 8/ ADM was resistant to DNR, VCR, MIT and CDDP in different degrees. L38/ADM细胞除对ADM耐药外,对DNR、VCR、MIT和CDDP也有不同程度的耐药性。
Objective To study the relationship between Cisplatin ( CDDP) and radiation used in combination in human laryngeal squamous cells ( Hep-2), in order to determine the optimum sequence of the two treatments, and the relations with telomerase activity. 目的研究CDDP和放疗联合应用于人喉鳞状细胞癌细胞的相互作用,以探讨放、化疗两种处理方式应用的顺序及与端粒酶活性的关系。
Objective To investigate the expression of N-methylpurine-DNA-Glycosylase in lung cancer H446/ CDDP multidrug-resistance cell line. 目的本研究旨在观察N-甲基化嘌呤-DNA-糖基化酶在小细胞肺癌多药耐药细胞系H446/CDDP中的表达情况。
Study of the proliferation and apoptosis in drug-resistant cell line tca8113/ cddp induced by tgf-β_1 TGF-β1对耐药细胞系Tca8113/CDDP增殖和凋亡影响的研究
Sensitivity of the Gastric Cancer Cell Lines to the Anti-Cancer Drugs CDDP, DXP, VP-16 顺铂、阿霉素和VP-16在胃癌细胞系中药物敏感性的研究
[ Method] Sensitivities of ADM and CDDP on HCC were studied by primary cell culture. 〔方法〕采用原代细胞培养技术,研究18例HCC对ADM和CDDP的敏感性。
The integrity of plasma membrane of BGC-823 cells was destroyed at the early stage of CDDP treatment. 顺铂作用早期BGC-823细胞膜的完整性就被破坏;
Using hollow magnetic nanoparticles as drug carriers and CDDP as the model drug, we researched its release behavior. 用所制备的中空纳米粒子为载体,负载抗癌药物顺铂,对其缓释性能进行了研究。