Role of Transcription Factor MafA in Pancreatic Island β Cells 转录因子MafA在胰岛β细胞中的作用
We have been studying that hepatocytes can be induced into pancreatic B-cells through the introduction of a few factors on islet development ( such as Pdx-1, MafA and Ngn3). 我们查阅了大量文献都表明,向肝脏细胞引入一个多个胰岛发育的关键因子(如Pdx1、MafA及Ngn3)可以使肝细胞向胰岛细胞的方向进行转化。
GSK3 may activate insulin 2 gene expression by phosphorylating MafA in rat INS-1 cells. 大鼠INS-1细胞中,GSK3可能通过磷酸化MafA蛋白,进而促进insulin2基因表达。
In currently found, the MafA gene can induce insulin secretion in vitro, and has great significance to the treatment to the diabetes. 目前发现,MafA基因能够诱导体外胰岛素分泌,对糖尿病的治疗有重大的意义。