The keratinocyte stem cells ( KSC) are located in epidermal basal layer and play a central role in tissue self-renewal, wound healing and neoplasm formation. 皮肤组织具有很强的再生能力,基底层中的表皮干细胞(keratinocytestemcells,KSC)在组织自我更新、损伤修复和肿瘤发生中起重要作用。
Objective To construct small interfering RNA ( siRNA) expression vectors specific to integrin β 1 and study the role of integrin β 1 in regulating human keratinocyte stem cell ( KSC) prolifer-ation and differentiation in vitro. 目的构建针对整合索(intergrin)β1特异性的siRNA表达载体,并转染人表皮干细胞(KSC),探讨整合素β1对KSC增殖与分化的影响。
Conclusion: KSC is a hopeful biological response modifier in cancer biotherapy, and tumor killing effector cells and chemotherapy plus BRM might be a promising candidate for human leukemia biotherapy. 结论:硒酸酯多糖是一种实用而有效的生物反应调节剂,肿瘤杀伤效应细胞+化疗+生物反应调节剂方案是一种白?
Results: 1.The distribution of KSC in different skins: ( 1). 不同来源的皮肤中干细胞的分布及含量差异:(1)。
Then proved that it is one kind of convexity between KUC and KSC, and as one concept, KDC is the dual concept of KSS better than KSC is. 然后证明了它是介于KUC和KSC之间的一种凸性。进而说明了KDC作为KSS的对偶性质比KSC更为恰当。
And the cells were identified by monoclone antibody of β 1 integrin and cytokeratin 19 ( Ck19), then the image analysis was done. 体外培养扩增后,以KSC的相对特异性标识分子β1整合素、角蛋白19(Ck19)的单克隆抗体,免疫组织化学方法对各组细胞进行鉴定,利用图像分析系统测平均灰度值。
KSC have become ideal research target cells in gene transfer, since abnormal epidermal gene expression can be regulated through stem cell gene transfer. KSC已成为转基因理想的靶细胞,可通过干细胞的基因转移来调节表皮异常基因表型;